Cancer and aging - An evolving panorama
Cancer and aging - An evolving panorama
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DOI：
10.1016/s0889-8588(05)70274-4
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发表时间：
2000-02-01
影响因子：
2.4
通讯作者：
Extermann, M
中科院分区：
文献类型：
--
作者：
Balducci, L;Extermann, M
随着普通人口的老龄化，癌症与老龄化之间的联系正变得越来越普遍。这种联系带来了与癌症的发病机制、生物学、管理和预防有关的问题。衰老可能使人们更容易患上癌症，因为衰老的许多分子变化与早期致癌变化平行。衰老可能通过两种不同的机制影响癌症生长：不同的癌症(急性髓系白血病)、不同的肿瘤宿主(大细胞非霍奇金淋巴瘤)或两者的组合(乳腺癌)。老年人癌症的预防可包括化学预防和筛查。对老年人癌症的管理是基于对综合老年评估所提供的风险和益处的评估。
The association of cancer and aging is becoming more common with the aging of the general population. This association brings about questions related to the pathogenesis, biology, management, and prevention of cancer. Aging may predispose people to cancer because many of the molecular changes of aging parallel early carcinogenic changes. Aging may influence cancer growth by two different mechanisms: different cancers (acute myelogenous leukemia), different tumor host (large cell non-Hodgkin's lymphoma), or a combination of both (breast cancer). Prevention of cancer in older persons may include both chemoprevention and screening. The management of cancer in the older person is based on an assessment of risks and benefits provided by comprehensive geriatric assessment.