Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction.
Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction.
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DOI：
10.1038/s41598-017-03894-4
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发表时间：
2017-06-15
影响因子：
4.6
通讯作者：
Miwa T
中科院分区：
文献类型：
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作者：
Shiga H;Taki J;Okuda K;Watanabe N;Tonami H;Nakagawa H;Kinuya S;Miwa T
特发性嗅觉障碍对治疗有抵抗力，恢复时间长。本研究调查了经鼻给药的 201 铊迁移到嗅球（铊迁移到 OB）的预后价值，这是特发性嗅觉障碍患者嗅觉神经损伤的一种测量方法。 24 名特发性嗅觉障碍患者参与了这项研究（7 名女性和 17 名男性；年龄 23-73 岁）。我们回顾性分析了在接受日本草药 Tokishakuyakusan 常规治疗之前接受基于铊的嗅觉成像（鼻腔施用铊 201）的受试者的潜在预后标志物，并将这些数据与预后进行比较。进行对数秩检验以评估铊向 OB 迁移（<4.6%[低]与≥4.6%[高]；数据以最佳截止值二分）与治疗后通过标准嗅觉功能测试（T&T 嗅觉测量）确定的气味识别阈值恢复的持续时间之间的关系。经过统计分析，我们发现铊向产科的迁移量高与患者更好的预后显着相关。我们的结果表明，可以使用基于铊的成像来选择具有完整嗅觉神经纤维的患者，以对嗅觉功能障碍进行长期随访。
Idiopathic olfactory disorder is resistant to treatment, and the recovery time is long. This study investigated the prognostic value of the migration of nasally administered thallium-201 to the olfactory bulb (thallium migration to the OB), a measure of olfactory nerve damage, in patients with idiopathic olfactory disorders. Twenty-four patients with idiopathic olfactory disorders were enrolled in the study (7 women and 17 men; aged 23–73 years). We retrospectively analyzed potential prognostic markers in subjects who underwent thallium-based olfactory imaging with the nasal administration of thallium-201 before conventional treatment with the Japanese herbal medicine tokishakuyakusan and compared those data with the prognosis. Log-rank tests were performed to assess the relationship between thallium migration to the OB (<4.6% [low] vs. ≥4.6% [high]; data dichotomized at the optimal cutoff value) and the duration until recovery of the odor recognition threshold determined by a standard olfactory function test (T&T olfactometry) after the treatment. Upon statistical analysis, we found that high thallium migration to the OB was significantly correlated with better prognosis in patients. Our results suggest that patients with intact olfactory nerve fibers could be selected using thallium-based imaging for the long-term follow-up of olfactory dysfunction.