REPRODUCTIVE HISTORY AND GASTRIC-CANCER AMONG POSTMENOPAUSAL WOMEN
REPRODUCTIVE HISTORY AND GASTRIC-CANCER AMONG POSTMENOPAUSAL WOMEN
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DOI：
10.1002/ijc.2910560609
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发表时间：
1994-03-15
影响因子：
6.4
通讯作者：
BUIATTI, E
中科院分区：
文献类型：
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作者：
PALLI, D;CIPRIANI, F;BUIATTI, E
在意大利进行的一项多中心研究中，共对339名绝经后胃癌（GC）妇女和515名对照人群进行了访谈，以了解有关生殖史、饮食习惯和其他社会人口统计学变量的信息。在调整这些因素后，报告绝经年龄低于45岁的女性中GC风险显著较高，而初潮年龄，产次，首次活产年龄和堕胎次数无影响。当绝经年龄与初潮年龄一起被认为是生育指数时，GC风险与生育持续时间呈显著负相关。这些结果表明，内分泌或其他因素的保护作用，在绝经后期年龄或生育力的长度。这些发现可能有助于解释世界各地女性报告的GC发生率低于男性的事实，并表明需要进一步研究激素和其他相关风险因素。(C)1994 Wiley-Liss，Inc.
A total of 339 post-menopausal women with gastric cancer (GC) and 515 population controls were interviewed in a multicenter study in Italy for information on reproductive history, dietary habits and other socio-demographic variables. After adjusting for these factors, GC risk was significantly higher among women reporting menopause below age 45, while no effect was shown for age at menarche, parity, age at first livebirth, and number of abortions. When age at menopause was considered together with age at menarche for an index of fertility years, GC risk showed a significant inverse relation to duration of fertility. These results suggest a protective role for endocrine or other factors related to late age at menopause or to length of fertility. These findings may be relevant to explain the fact that rates of GC reported among females are lower than among males around the world, and suggest the need for further research into hormonal and other related risk factors. (C) 1994 Wiley-Liss, Inc.