Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats
Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats
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DOI：
10.7717/peerj.7460
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发表时间：
2019-09-23
期刊：
影响因子：
2.7
通讯作者：
El-Shenawy, Nahla S.
中科院分区：
文献类型：
--
作者：
Hamza, Reham Z.;Al-Salmi, Fawziah A.;El-Shenawy, Nahla S.
背景谷氨酸钠（MSG）被广泛用作世界上许多国家饮食中的食品添加剂。研究目的。我们的目的是确定绿色氧化锌纳米颗粒对MSG诱导的大鼠大脑皮质氧化损伤、神经递质变化和组织病理学改变的影响。MSG以6和17.5 mg/kg体重的两个剂量口服给药。高剂量组大鼠大脑皮层超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶活性以及脑源性神经营养因子（BDNF）和谷胱甘肽（GSH）水平显著下降。向17.5 mg/kg MSG治疗的大鼠给予氧化锌纳米颗粒/绿色茶提取物（ZnO NPs/GTE）与之前显示由MSG改变的所有参数的显着改善相关。高剂量的MSG可引起脑组织明显的病理变化。ZnO NPs/GTE和MSG-HD联合治疗大鼠可抑制MSG引起的神经递质和乙酰胆碱酯酶的降低。ZnO NPs/GTE具有保护MSG-HD诱导的氧化应激和神经元坏死的潜力。ZnO NP/GTE比对照治疗或单独施用的ZnO NP或GTE赋予更大的益处。
Background. Monosodium glutamate (MSG) is used extensively as a food additive in the diets of many countries around the world.Aim of the study. Our aim was to determine the effects of green zinc oxide nanoparticles on MSG-induced oxidative damage, neurotransmitter changes, and histopathological alternation in the cerebral cortexes of rats.Methods. MSG was administered orally at two doses of 6 and 17.5 mg/kg body weight. The higher dose was associated with a significant decline in the activities of superoxide dismutase, catalase, and glutathione peroxidase, as well as the levels of brain-derived neurotrophic factor (BDNF) and glutathione (GSH) in the cerebral cortex of rats.Results. The administration of zinc oxide nanoparticles/green tea extract (ZnO NPs/GTE) to 17.5 mg/kg MSG-treated rats was associated with significant improvements in all parameters previously shown to be altered by MSG. The higher dose of MSG induced significant histopathological variation in brain tissue. Co-treatment of rats with ZnO NPs/GTE and MSG-HD inhibited the reduction of neurotransmitters and acetylcholinesterase by MSG.Conclusions. ZnO NPs/GTE have the potential to protect against oxidative stress and neuronal necrosis induced by MSG-HD. ZnO NPs/GTE conferred a greater benefit than the control treatment or ZnO NPs or GTE administered separately.