CEREBRAL STRUCTURE ON MRI .2. SPECIFIC CHANGES IN ALZHEIMERS AND HUNTINGTONS DISEASES
CEREBRAL STRUCTURE ON MRI .2. SPECIFIC CHANGES IN ALZHEIMERS AND HUNTINGTONS DISEASES
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DOI：
10.1016/0006-3223(91)90211-4
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发表时间：
1991-01-01
影响因子：
10.6
通讯作者：
HESSELINK, JR
中科院分区：
文献类型：
--
作者：
JERNIGAN, TL;SALMON, DP;HESSELINK, JR
采用磁共振（MR）成像和形态测量技术，将老年痴呆症（AD）和亨廷顿病（HD）患者组与一大组正常对照组进行比较。测量特定皮质下核和8个皮质区域的体积损失以及白质异常指数。结果表明，阿尔茨海默病患者的皮质体积普遍减少，其中内侧皮质体积减少尤为严重；但在皮层下结构，尤其是丘脑，也出现了类似的减少。在HD中，纹状体结构减少最多，但在丘脑和下皮层区域也发现了明显的异常，特别是在内侧颞叶结构。两组患者均有明显的白质变性，但在HD患者中更为明显。间脑AD的显著减少可能对该疾病的早期记忆缺陷做出重要贡献，这通常归因于海马损伤。同样，丘脑和内侧颞叶结构的损伤可能在HD的记忆缺陷中起作用。
Using magnetic resonance (MR) imaging and morphometric techniques, groups of patients with Alzheimer's disease (AD) and Huntington's disease (HD) were compared with a large group of normal control subjects. Measures of volume loss in specific subcortical nuclei and eight cortical regions as well as an index of white matter abnormality were obtained. Results indicated expected widespread cortical volume reductions in AD, which were especially severe in mesial cortices; but comparable reductions were present in subcortical structures, particularly the thalamus. In HD, the greatest reductions were in striatal structures, but significant abnormalities were also detected in the thalamus and inferior cortical areas, especially in mesial temporal lobe structures. Significant degeneration in white matter was present in both groups, but was more dramatic in the HD patients. The significant diencephalic reduction in AD may make an important contribution to early memory deficits in the disorder, which are usually attributed to hippocampal damage. Similarly, damage to both the thalamus and mesial temporal lobe structures may play a role in the memory deficits of HD.