Lipid tubule growth by osmotic pressure.
Lipid tubule growth by osmotic pressure.
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脂质小管通过渗透压生长。
DOI：
10.1098/rsif.2013.0637
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Shen,AmyQ
中科院分区：
文献类型：
--
作者：
Rangamani,Padmini;Zhang,Di;Oster,George;Shen,AmyQ
我们在此提出一种体外培养脂质小管的方法。这种方法使我们能够生长出形状和结构一致的小管，因此可以成为纳米工程应用的有用工具。小管的生长过程分为起始、延伸和终止三个阶段。平衡作用于小管头部的力表明，在延伸阶段，小管的生长取决于渗透压力和基底和外部流体施加在膜上的粘性阻力之间的平衡。利用数学建模和实验相结合，我们确定了在延伸阶段控制小管生长的关键力量。
We present here a procedure for growing lipid tubulesin vitro. This method allows us to grow tubules of consistent shape and structure, and thus can be a useful tool for nano-engineering applications. There are three stages during the tubule growth process: initiation, elongation and termination. Balancing the forces that act on the tubule head shows that the growth of tubules during the elongation phase depends on the balance between osmotic pressure and the viscous drag exerted on the membrane from the substrate and the external fluid. Using a combination of mathematical modelling and experiment, we identify the key forces that control tubule growth during the elongation phase.