Abdominal Imaging in ADPKD: Beyond Total Kidney Volume.
Abdominal Imaging in ADPKD: Beyond Total Kidney Volume.
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DOI：
10.3390/jcm12155133
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发表时间：
2023-08-05
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
在常染色体显性遗传性多囊肾病（ADPKD）的背景下，测量肾脏总体积（TKV）至关重要。它作为跟踪疾病进展和评估治疗策略有效性的标志物。TKV也被认为是一种富集生物标志物和临床试验中可能的替代终点。有几种成像模式和方法可用于计算TKV，选择取决于使用目的。技术进步使得准确评估囊肿负担成为可能，这对于评估疾病状态和帮助识别快速进展者至关重要。此外，自动化算法的开发提高了总肾脏和囊肿体积测量的效率。除了这些测量之外，非囊性肾组织的定量和表征显示出对ADPKD患者进行早期分层、监测疾病进展以及可能预测肾功能丧失的潜力。广泛的放射成像技术可用于表征肾脏组织，在非侵入性地拾取ADPKD进展的早期迹象时显示出希望。放射组学已被用来提取ADPKD图像的纹理特征，提供有关囊性和非囊性成分的异质性的有价值的信息。本文综述了ADPKD影像学生物标志物的概况，重点介绍了定量方法，潜力和成功转化为临床实践的必要步骤。
In the context of autosomal dominant polycystic kidney disease (ADPKD), measurement of the total kidney volume (TKV) is crucial. It acts as a marker for tracking disease progression, and evaluating the effectiveness of treatment strategies. The TKV has also been recognized as an enrichment biomarker and a possible surrogate endpoint in clinical trials. Several imaging modalities and methods are available to calculate the TKV, and the choice depends on the purpose of use. Technological advancements have made it possible to accurately assess the cyst burden, which can be crucial to assessing the disease state and helping to identify rapid progressors. Moreover, the development of automated algorithms has increased the efficiency of total kidney and cyst volume measurements. Beyond these measurements, the quantification and characterization of non-cystic kidney tissue shows potential for stratifying ADPKD patients early on, monitoring disease progression, and possibly predicting renal function loss. A broad spectrum of radiological imaging techniques are available to characterize the kidney tissue, showing promise when it comes to non-invasively picking up the early signs of ADPKD progression. Radiomics have been used to extract textural features from ADPKD images, providing valuable information about the heterogeneity of the cystic and non-cystic components. This review provides an overview of ADPKD imaging biomarkers, focusing on the quantification methods, potential, and necessary steps toward a successful translation to clinical practice.
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影响因子：
168.9
作者：
Caroli, Anna;Perico, Norberto;Ruggenenti, Piero
通讯作者：
Ruggenenti, Piero
DOI：
10.26355/eurrev_202109_26795
发表时间：
2021-01-01
影响因子：
3.3
作者：
Cong, L.;Hua, Q-Q;Ma, T.
通讯作者：
Ma, T.
DOI：
10.1093/ndt/gfy163
发表时间：
2018-09-01
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Caroli A;Schneider M;Friedli I;Ljimani A;De Seigneux S;Boor P;Gullapudi L;Kazmi I;Mendichovszky IA;Notohamiprodjo M;Selby NM;Thoeny HC;Grenier N;Vallée JP
通讯作者：
Vallée JP
影响因子：
4.2
作者：
Bae, Kyongtae T.;Tao, Cheng;Landsittel, Doug P.
通讯作者：
Landsittel, Doug P.
影响因子：
3.3
作者：
Bokacheva, Louisa;Rusinek, Henry;Lee, Vivian S.
通讯作者：
Lee, Vivian S.