Optical coherence tomography: technology and applications
Optical coherence tomography: technology and applications
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DOI：
10.1109/omems.2002.1031485
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发表时间：
2002-11
期刊：
影响因子：
--
通讯作者：
J. Fujimoto
中科院分区：
文献类型：
--
作者：
J. Fujimoto
光学相干层析成像(OCT)是一种新兴的生物医学成像手段，它可以生成生物系统微观结构的高分辨率断层图像。OCT类似于B超成像，不同的是它使用光而不是声音。由于光速极高，直接的电子探测是不可能的，成像是使用低相干度干涉法进行的。来自样品或组织的光的回波与传播已知参考路径长度的光相关或干扰。OCT图像是通过测量组织中光学后向散射的回波时间延迟作为横向位置的函数来产生的，并且数据可以显示为假彩色或灰度图像。轴向分辨率由光源的相干长度决定。成像分辨率可达1~15微米/微米。
Optical coherence tomography (OCT) is an emerging biomedical imaging modality which can generate high resolution, cross-sectional images of microstructure in biological systems. OCT is analogous to ultrasound B mode imaging, except that it uses light instead of sound. Because the velocity of light is extremely high, direct electronic detection is not possible and imaging is performed using low coherence interferometry. Echoes of light from the specimen or tissue are correlated or interfered with light that travels a known reference path length. OCT images are generated by measuring the echo time delay of optical backscattering in the tissue as a function of transverse position and the data can be displayed as a false color or grey scale image. The axial resolution is determined by the coherence length of the light source. Imaging resolutions of 1 to 15 /spl mu/m can be achieved.