Exposure to postnatal depression predicts elevated cortisol in adolescent offspring
Exposure to postnatal depression predicts elevated cortisol in adolescent offspring
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DOI：
10.1016/j.biopsych.2003.09.013
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发表时间：
2004-02-15
影响因子：
10.6
通讯作者：
Murray, L
中科院分区：
文献类型：
--
作者：
Halligan, SL;Herbert, J;Murray, L
背景动物研究表明，早期的不良经历会导致成年期糖皮质激素水平的改变，要么是基础水平升高，要么是对压力的反应加剧。如果类似的现象在人类中起作用，这表明一种生物学机制，即早期逆境可能会传递重度抑郁症的风险，糖皮质激素升高与这种疾病的发展有关。我们测量了13岁的青少年在上午8：00和下午8：00超过10天的唾液皮质醇，这些青少年有（n = 48）或没有（n = 39）暴露于产后母亲depress.Results：母亲产后抑郁症与后代更高，更可变的早晨皮质醇相关，这是以前发现的预测重度抑郁症的模式。早期的不良经历可能会改变人类后来的类固醇水平。因为母亲抑郁症会增加孩子患抑郁症的风险，这些改变可能会在早期事件和后来的精神病理学之间提供联系。
Background. Animal research shows that early adverse experience results in altered glucocorticoid levels in adulthood, either raised basal levels or accentuated responses to stress. If a similar phenomenon operates in humans, this suggests a biological mechanism whereby early adversity might transmit risk for major depression, glucocorticoid elevations being associated with the development of this disorder.Methods. We measured salivary cortisol at 8:00 Am and 8:00 Pm over 10 days in 13-year-old adolescents who had (n = 48) or bad not (n = 39) been exposed to postnatal maternal depression.Results: Maternal postnatal depression was associated with higher, more variable morning cortisol in offspring, a pattern previously found to predict major depression.Conclusions. Early adverse experiences might alter later steroid levels in humans. Because maternal depression confers added risk for depression to children, these alterations might provide a link between early events and later psychopathology.