Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system
Ferulic acid chronic treatment exerts antidepressant-like effect: role of antioxidant defense system
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DOI：
10.1007/s11011-015-9725-6
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发表时间：
2015-12-01
影响因子：
3.6
通讯作者：
Bertarello Zeni, Ana Lucia
中科院分区：
文献类型：
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作者：
Lenzi, Juliana;Rodrigues, Andre Felipe;Bertarello Zeni, Ana Lucia
氧化应激在抑郁症的病理生理中占有重要地位；然而，这种情况的神经生物学细节仍然不完全清楚。最近，使用抗氧化剂的治疗方法得到了深入的研究。阿魏酸（FA）是一种具有抗氧化和抗抑郁作用的酚类化合物。本研究采用小鼠悬尾实验（TST）和强迫游泳实验（FST）研究慢性口服FA治疗抗氧化活性在其抗抑郁样作用中的作用。通过TST和FST评估应激诱导后血液、海马和大脑皮层抗氧化系统的调节。结果表明，1 mg/kg剂量的FA具有抗抑郁样作用，但不影响运动活性。绝望应激可显著降低大鼠血液中超氧化物歧化酶（SOD）、血液中过氧化氢酶（CAT）和大脑皮层中谷胱甘肽过氧化物酶（GSH-Px）的活性。大脑皮层中硫代巴比妥酸反应物质（TBA-RS）水平显著升高。此外，结果表明，FA能够提高血液、海马和大脑皮层中SOD、CAT和GSH-Px活性，降低TBA-RS水平。这些发现表明，低剂量FA治疗能够发挥抗抑郁样作用，并参与抗氧化防御系统调节。
Oxidative stress has been claimed a place in pathophysiology of depression; however, the details of the neurobiology of this condition remains incompletely understood. Recently, treatments employing antioxidants have been thoroughly researched. Ferulic acid (FA) is a phenolic compound with antioxidant and antidepressant-like effects. Herein, we investigated the involvement of the antioxidant activity of chronic oral FA treatment in its antidepressant-like effect using the tail suspension test (TST) and the forced swimming test (FST) in mice. The modulation of antioxidant system in blood, hippocampus and cerebral cortex was assessed after stress induction through TST and FST. Our results show that FA at the dose of 1 mg/kg has antidepressant-like effect without affecting locomotor activity. The stress induced by despair tests was able to decrease significantly the activities of superoxide dismutase (SOD) in the blood, catalase (CAT) in the blood and cerebral cortex and glutathione peroxidase (GSH-Px) in the cerebral cortex. Thiobarbituric acid-reactive substances (TBA-RS) levels were increased significantly in the cerebral cortex. Furthermore, the results show that FA was capable to increase SOD, CAT and GSH-Px activities and decrease TBA-RS levels in the blood, hippocampus and cerebral cortex. These findings demonstrated that FA treatment in low doses is capable to exert antidepressant-like effect with the involvement of the antioxidant defense system modulation.