Highly crosslinked, PEG-containing copolymers for sustained solute delivery.
Highly crosslinked, PEG-containing copolymers for sustained solute delivery.
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DOI：
10.1016/s0142-9612(99)00040-x
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发表时间：
1999-08
期刊：
影响因子：
14
通讯作者：
Robert A. Scott;N. Peppas
中科院分区：
文献类型：
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作者：
Robert A. Scott;N. Peppas
采用本体自由基光聚合技术，以丙烯酸（AA）和低聚乙二醇（OEG）为单体，制备了新型的可电离聚合物网络。这些材料的性能表现出复杂的网络结构和组成的依赖性，因此，该材料被用于控制释放装置的设计与精确控制的性能。模型溶质proxyphylline的释放动力学表现出很强的成分依赖性，与测得的扩散系数变化超过几个数量级，取决于聚合物网络结构和释放介质的pH值。改变OEG链长提供了粗略调节丙茶碱释放速率的手段，而改变AA含量和pH提供了更精确的控制措施。
Novel ionizable polymer networks were prepared from oligo(ethylene glycol) (OEG) multiacrylates and acrylic acid (AA) employing bulk radical photopolymerization techniques. The properties of these materials exhibited a complex dependence on the network structure and composition, and the materials were therefore used in the design of controlled release devices with precisely controlled properties. The release kinetics of model solute proxyphylline exhibited a strong compositional dependence, with measured diffusion coefficients varying over several orders of magnitude, depending on the polymer network structure and the pH of the release medium. Varying the OEG chain length provided a means of coarsely adjusting the proxyphylline release rate, while varying the AA content and the pH offered a more precise measure of control.