Evidence of altered cortical and amygdala activation during social decision-making in schizophrenia
Evidence of altered cortical and amygdala activation during social decision-making in schizophrenia
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DOI：
10.1016/j.neuroimage.2007.12.039
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发表时间：
2008-04-01
期刊：
影响因子：
5.7
通讯作者：
Kahn, Rene S.
中科院分区：
文献类型：
--
作者：
Baas, Daan;Aleman, Andre;Kahn, Rene S.
社会认知障碍是精神分裂症的常见致残特征。社会认知的一个重要方面涉及对他人做出社会决策。本研究调查了精神分裂症患者和健康对照组之间与社会决策相关的大脑活动是否存在差异。12名精神分裂症患者和21名对照受试者参加了这项研究。在一项涉及判断面孔可信度的任务中，对行为表现和大脑活动进行了评估。我们进行了基于兴趣区域的分析，结果显示，精神分裂症患者在社会决策过程中，其内侧眶额皮质、杏仁核和右脑岛的激活有特定的增加和减少，这些区域在社会决策的基础网络中起着关键作用。这些发现表明，在精神分裂症中经常观察到的社会认知障碍，至少部分地与这些区域的大脑活动改变有关。(c) 2007爱思唯尔公司版权所有。
Impaired social cognition is a frequently observed and disabling characteristic of schizophrenia. An important aspect of social cognition involves making social decisions about others. The present study investigates whether brain activity related to social decision-making differs between patients with schizophrenia and healthy controls. Twelve patients with schizophrenia and 21 control subjects participated in the study. Behavioral performance and brain activity were assessed during a task that involved judging the trustworthiness of faces. We performed region-of-interest-based analyses, which revealed that patients with schizophrenia display specific increases and reductions in activation of the medial orbitofrontal cortex, amygdala and the right insula during social decision-making, areas that play key roles in the network that underlies social decisions. These findings suggest that the impairments in social cognition that are often observed in schizophrenia are, at least in part, related to altered brain activity in these areas. (c) 2007 Elsevier Inc. All rights reserved.