Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance
Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance
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DOI：
10.2337/diacare.24.12.2127
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发表时间：
2001-12-01
期刊：
影响因子：
16.2
通讯作者：
Takahashi, M
中科院分区：
文献类型：
--
作者：
Nagaretani, H;Nishizawa, H;Takahashi, M
目的：评估日本糖耐量受损（IGT）男性腹部内脏脂肪积累的意义。研究设计和方法- IGT受试者（n = 123）年龄55 +/- 9岁，BMI为24 +/- 3 kg/m(2)。148例糖耐量（NGT）正常的对照受试者进行年龄和BMI匹配。IGT和NGT是根据1985年世界卫生组织的标准分类的。腹部脂肪分布通过脐层ct分析。测量血脂、葡萄糖、胰岛素浓度和血压（BP）。结果：IGT患者的平均内脏脂肪面积（VFA）明显大于NGT患者。空腹胰岛素、口服葡萄糖耐量试验期间胰岛素浓度和胰岛素抵抗（HOMA-IR）、收缩压和血清甘油三酯显著升高，而IGT受试者的DeltaI(30-0)/DeltaG（30-0）显著降低。然后，IGT和NGT患者根据他们拥有的危险因素（血脂异常、高血压、无危险因素或两者都有危险因素）的数量分为三个亚组。在IGT和NGT受试者中，双危险因素亚组的BMI、VFA、皮下脂肪面积、空腹胰岛素、HOMA-IR和体内平衡模型评估的胰岛素分泌显著高于无危险因素亚组，VFA是与双危险因素存在相关的一个强有力的独立变量。结论：内脏脂肪堆积是日本IGT和NGT患者多重危险因素聚集的主要因素。
OBJECTIVE - The significance of abdominal visceral fat accumulation was evaluated in Japanese men with impaired glucose tolerance (IGT).RESEARCH DESIGN AND METHODS - The IGT subjects (n = 123) were aged 55 +/- 9 years with a BMI of 24 +/- 3 kg/m(2). The 148 control subjects with normal glucose tolerance (NGT) were matched for age and BMI. IGT and NGT were classified according to the 1985 World Health Organization criteria. Abdominal fat distribution was analyzed by computed tomography at umbilical level. Plasma lipid, glucose, and insulin concentrations and blood pressure (BP) were measured.RESULTS - In subjects with IGT, the average visceral fat area (VFA) was significantly greater than in subjects with NGT. Fasting insulin, the sum of insulin concentrations during an oral glucose tolerance test, insulin resistance according to a homeostasis model assessment for insulin resistance (HOMA-IR), systolic BP, and serum triglyceride were significantly higher, whereas the DeltaI(30-0)/DeltaG(30-0) was significantly lower, in subjects with IGT. Subjects with IGT and NGT were then divided into three subgroups according to the number of risk factors they possessed (dyslipidemia, hypertension, neither, or both). In both IGT and NGT subjects, BMI, VFA, subcutaneous fat area, fasting insulin, HOMA-IR, and insulin secretion of the homeostasis model assessment were significantly higher in the double-risk factor subgroup than in the no-risk factor subgroup, and VFA was a potent and independent variable in association with the presence of a double risk factor.CONCLUSIONS - Visceral fat accumulation is a major contributor for multiple risk factor clustering in Japanese men with IGT and NGT.