The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment.
The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment.
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DOI：
10.3390/cells10061447
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发表时间：
2021-06-09
期刊：
影响因子：
6
通讯作者：
Tschan MP
中科院分区：
文献类型：
--
作者：
Niklaus NJ;Tokarchuk I;Zbinden M;Schläfli AM;Maycotte P;Tschan MP
大自噬（Macroautophagy）（本文中称为自噬）是一种复杂的分解代谢过程，其特征在于形成称为自噬体的双膜囊泡。在此过程中，自噬体吞噬并将其细胞内内容物递送到溶酶体，在那里它们被水解酶降解。因此，自噬提供能量和构建模块以维持细胞内稳态，并代表动态再循环机制。重要的是，在正常细胞中通过自噬清除受损的细胞器和聚集的分子有助于癌症预防。因此，自噬功能障碍对细胞命运具有重大影响，并可能有助于肿瘤发生。乳腺癌是妇女最常见的癌症，在全世界妇女所有癌症中死亡率最高。乳腺癌患者通常有良好的短期预后，但长期生存者往往会经历积极的复发。这种现象可能是由于乳腺癌肿瘤的高度异质性使得乳腺肿瘤难以靶向。本文综述了自噬在乳腺癌发生过程中的作用机制，并阐明了自噬在侵袭性乳腺癌细胞迁移、侵袭和耐药性等特征中的作用。
Macroautophagy (herein referred to as autophagy) is a complex catabolic process characterized by the formation of double-membrane vesicles called autophagosomes. During this process, autophagosomes engulf and deliver their intracellular content to lysosomes, where they are degraded by hydrolytic enzymes. Thereby, autophagy provides energy and building blocks to maintain cellular homeostasis and represents a dynamic recycling mechanism. Importantly, the clearance of damaged organelles and aggregated molecules by autophagy in normal cells contributes to cancer prevention. Therefore, the dysfunction of autophagy has a major impact on the cell fate and can contribute to tumorigenesis. Breast cancer is the most common cancer in women and has the highest mortality rate among all cancers in women worldwide. Breast cancer patients often have a good short-term prognosis, but long-term survivors often experience aggressive recurrence. This phenomenon might be explained by the high heterogeneity of breast cancer tumors rendering mammary tumors difficult to target. This review focuses on the mechanisms of autophagy during breast carcinogenesis and sheds light on the role of autophagy in the traits of aggressive breast cancer cells such as migration, invasion, and therapeutic resistance.
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DOI：
10.1158/1078-0432.ccr-13-3227
发表时间：
2014-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cook KL;Wärri A;Soto-Pantoja DR;Clarke PA;Cruz MI;Zwart A;Clarke R
通讯作者：
Clarke R
影响因子：
4.3
作者：
Choudhury, Sujata;Kolukula, Vamsi K.;Avantaggiati, Maria Laura
通讯作者：
Avantaggiati, Maria Laura
影响因子：
4.3
作者：
Alayev, Anya;Sun, Yang;Holz, Marina K.
通讯作者：
Holz, Marina K.
影响因子：
4.5
作者：
Audesse, Amanda J.;Dhakal, Shleshma;Webb, Ashley E.
通讯作者：
Webb, Ashley E.
影响因子：
4
作者：
Alhoshani A;Alatawi FO;Al-Anazi FE;Attafi IM;Zeidan A;Agouni A;El Gamal HM;Shamoon LS;Khalaf S;Korashy HM
通讯作者：
Korashy HM