Twice daily short-message-based re-education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study
Twice daily short-message-based re-education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study
复制标题
每日两次短信再教育可提高年轻人幽门螺杆菌根除率：一项前瞻性随机对照研究
DOI：
10.1111/hel.12569
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发表时间：
2019-06-01
期刊：
影响因子：
4.4
通讯作者：
Zuo, Xiuli
中科院分区：
文献类型：
--
作者：
Wang, Tongyu;Yang, Xiaoxiao;Zuo, Xiuli
背景旨在研究在服药前每天两次基于短信的再教育（SMRE）对幽门螺杆菌（Hpylori）根除的效果。材料和方法初治幽门螺杆菌感染患者接受为期 14 天的四联方案，包括兰索拉唑 30mg、胶体果胶铋 200mg、阿莫西林 1000mg、 克拉霉素 500 毫克，每日两次。患者被随机分配至 SMRE 组或对照组。对照组患者在门诊接受口头和书面指导。相比之下，SMRE 组的患者每天两次收到额外的短信，包括剂量和给药时间。治疗后 6 周使用 C-13-尿素呼气试验评估幽门螺杆菌根除是否成功。还分析了依从性、不良事件和患者满意度。结果共有 310 名患者参加了意向治疗 (ITT) 分析，283 名患者参加了符合方案 (PP) 分析。 PP分析中，对于年轻患者，SMRE组的根除率显着高于对照组（88.6% vs 71.2%，P=0.036），而对于所有年龄组的患者，根除率改善均无统计学意义。 ITT分析中SMRE组和对照组的根除率分别为74.2%和67.7%（P=0.211），PP分析中SMRE组和对照组的根除率分别为82.1%和73.4%（P=0.078）。 SMRE组的依从性明显优于对照组（84.8% vs 72.8%，P=0.011）。结论每天两次SMRE可以提高年轻人群的根除率，以及根除幽门螺杆菌期间的治疗依从性。
BackgroundTo investigate the effects of twice daily short-message-based re-education (SMRE) before taking medicine for Helicobacter pylori (Hpylori) eradication.Materials and MethodsTreatment-naive patients with Hpylori infection were prescribed 14-day quadruple regimen consisting of lansoprazole 30mg, colloidal bismuth pectin 200mg, amoxicillin 1000mg, and clarithromycin 500mg twice daily. Patients were randomly allocated to SMRE group or control group. Patients in control group received oral and written instructions at outpatient clinic. In contrast, patients in the SMRE group received extra short messages including dosage and time of administration twice daily. Successful Hpylori eradication was assessed using the C-13-urea breath test 6weeks after treatment. The compliance, adverse events, and patient satisfaction were also analyzed.ResultsA total of 310 patients were enrolled in the intention-to-treat (ITT) and 283 in the per-protocol (PP) analysis. For young patients, the eradication rates were significantly higher in SMRE group than those in control group in PP analysis (88.6% vs 71.2%, P=0.036), while for patients of all age groups, the eradication rate improvements were not statistically significant. The eradication rates in SMRE group and control group were 74.2% and 67.7% (P=0.211) in ITT analysis and 82.1% and 73.4% (P=0.078) in PP analysis, respectively. The compliance in SMRE group was significantly better than that in control group (84.8% vs 72.8%, P=0.011).ConclusionsTwice daily SMRE could improve the eradication rate in young population, as well as the compliance with treatment during Hpylori eradication.