Survival time of rats exposed to different high oxygen pressures after administration of perfluorochemicals.
Survival time of rats exposed to different high oxygen pressures after administration of perfluorochemicals.
复制标题
给予全氟化合物后暴露于不同高氧压力的大鼠的存活时间。
DOI：
10.1007/978-1-4684-7433-6_43
复制
发表时间：
1987
影响因子：
--
通讯作者：
J. Lutz
中科院分区：
文献类型：
--
作者：
M. Stark;J. Lutz
高压氧给药被认为可用于治疗厌氧菌感染（Cline和Turnbull，1985）以及肿瘤放射治疗（Fischer，Rockwell和Martin，1986），其中需要非常高的组织氧分压。最常用的氧气压力300 kPa（3 ATA）可能不足以达到这一目标。血液中必须有足够的氧容量，以维持较高的分压，即使在毛细血管的静脉端，当氧气消耗。如果血红蛋白保持氧化形式，则可以实现更有效的治疗。全氟化学品（PFC）的管理，增加氧分压升高下的氧容量可以帮助实现这一目标。然而，根据盖耶（1983）先前获得的结果判断，高压氧治疗结合PFC给药可预期显著增加氧毒性。为了验证这一假设，应用了高压氧，并测量了大鼠的存活时间，作为生物体在各种氧压下的总体耐受性的指标。发现生存时间比确定抽搐发作更准确。本研究的目的是在对照组和PFC处理组动物中建立氧张力和暴露致死持续时间之间的关系。
Hyperbaric oxygen administration is considered useful in the treatment of anaerobic infections (Cline and Turnbull, 1985) as well as in tumour radiation therapy (Fischer, Rockwell and Martin, 1986) where very high tissue partial pressures of oxygen are needed. The most commonly used oxygen pressure of 300 kPa (3 ATA) may not be sufficient to reach this goal. There must be sufficient oxygen capacity in the blood to maintain an elevated partial pressure even at the venous end of capillaries when oxygen is consumed. More effective treatment could be accomplished if haemoglobin were to remain in the oxygenated form. The administration of perfluorochemicals (PFC) which increase the oxygen capacity under elevated oxygen partial pressure can help in attaining this goal. However, as judged from previous results obtained by Geyer (1983), hyperbaric oxygen treatment combined with PFC administration can be expected to augment oxygen toxicity considerably. To test this supposition hyperbaric oxygen was applied and survival times were measured in rats as an index of the overall tolerance of the organism at various oxygen pressures. Survival time was found to give a more precise endpoint than the determination of the onset of convulsions. It was the goal of this study to establish the relationship between oxygen tension and lethal duration of exposure in both control and PFC-treated animals.
放射治疗中的全氟化学品和高压氧。
DOI：
10.1016/0360-3016(86)90421-9
发表时间：
1986
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Fischer,JJ;Rockwell,S;Martin,DF
通讯作者：
Martin,DF