Longitudinal Analysis of Neural Network Development in Preterm Infants
Longitudinal Analysis of Neural Network Development in Preterm Infants
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DOI：
10.1093/cercor/bhq035
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发表时间：
2010-12-01
期刊：
影响因子：
3.7
通讯作者：
Neil, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Smyser, Christopher D.;Inder, Terrie E.;Neil, Jeffrey J.
静息状态功能连接磁共振成像（fcMRI）的早产儿的研究中的应用，使评估的最早形式的大脑连接和表征其在人类大脑的早期发展。我们获得了90个纵向fcMRI数据集，来自一组早产儿，年龄从月经后26周（PMA）到PMA特定时间点的足月等效年龄。利用基于种子的相关性分析，我们确定了涉及不同皮层区域，丘脑和小脑的静息状态网络。确定的网络表现出区域可变的特定年龄的发展模式，与更成熟的形式组成的本地化的半球间的连接同伦的同行。解剖距离被发现在连接发展的速度中起着至关重要的作用。显着的差异，指出在长期控制与早产儿在长期等效的网络，包括在丘脑皮质连接神经发育的关键。默认模式网络的假定前体在足月对照婴儿中被检测到，但在早产儿中未被识别，包括那些足月的婴儿。网络成熟的识别模式反映了在整个重要的发育时期存在的结构和功能过程的复杂关系，并与该人群中神经发育的先前调查一致。
Application of resting state functional connectivity magnetic resonance imaging (fcMRI) to the study of prematurely born infants enables assessment of the earliest forms of cerebral connectivity and characterization of its early development in the human brain. We obtained 90 longitudinal fcMRI data sets from a cohort of preterm infants aged from 26 weeks postmenstrual age (PMA) through term equivalent age at PMA-specific time points. Utilizing seed-based correlation analysis, we identified resting state networks involving varied cortical regions, the thalamus, and cerebellum. Identified networks demonstrated a regionally variable age-specific pattern of development, with more mature forms consisting of localized interhemispheric connections between homotopic counterparts. Anatomical distance was found to play a critical role in the rate of connection development. Prominent differences were noted between networks identified in term control versus premature infants at term equivalent, including in the thalamocortical connections critical for neurodevelopment. Putative precursors of the default mode network were detected in term control infants but were not identified in preterm infants, including those at term equivalent. Identified patterns of network maturation reflect the intricate relationship of structural and functional processes present throughout this important developmental period and are consistent with prior investigations of neurodevelopment in this population.