Reactivity of mononuclear alkylperoxo copper(II) complex. O-O bond cleavage and C-H bond activation
Reactivity of mononuclear alkylperoxo copper(II) complex. O-O bond cleavage and C-H bond activation
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DOI：
10.1021/ja800443s
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发表时间：
2008-04-02
影响因子：
15
通讯作者：
Itoh, Shinobu
中科院分区：
文献类型：
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作者：
Kunishita, Atsushi;Ishimaru, Hirohito;Itoh, Shinobu
首次对一种新的单核烷基过氧基铜(II)配合物进行了详细的反应性研究，该配合物是由双(吡啶甲基)胺三齿配体负载的铜(II)配合物与CH3CN中6位苯基的苯基和过氧化异丙苯(CmOOH)反应生成的。由此得到的异丙基过氧基铜(II)络合物被发现发生了O-O键的均解断裂，并诱导了外源底物的C-H键活化，为铜单加氧酶的催化机理提供了重要的见解。
A detailed reactivity study has been carded out for the first time on a new mononuclear alkylperoxo copper(II) complex, which is generated by the reaction of copper(II) complex supported by the bis(pyridylmethyl)amine tridentate ligand containing a phenyl group at the 6-position of the pyridine donor groups and cumene hydroperoxide (CmOOH) in CH3CN. The cumylperoxo copper(II) complex thus obtained has been found to undergo homolytic cleavage of the O-O bond and induce C-H bond activation of exogenous substrates, providing important insights into the catalytic mechanism of copper monooxygenases.