Tea consumption and infarct-related ventricular arrhythmias: the determinants of myocardial infarction onset study.
Tea consumption and infarct-related ventricular arrhythmias: the determinants of myocardial infarction onset study.
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饮茶和梗塞相关的室性心律失常：心肌梗塞发病的决定因素研究。
DOI：
10.1080/07315724.2006.10719561
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发表时间：
2006
影响因子：
3.5
通讯作者：
Mittleman,MurrayA
中科院分区：
文献类型：
--
作者：
Mukamal,KennethJ;Alert,Marissa;Maclure,Malcolm;Muller,JamesE;Mittleman,MurrayA
背景：在急性心肌梗死患者中，饮茶与较低的梗死后死亡率相关。我们以前发现的初步证据表明，茶叶消费也可能与梗死相关的室性心律失常的风险较低。方法：在1989年和1996年之间，3882例AMI患者入选了两个阶段的心肌梗死发病研究的决定因素中位数入院后4天。经过培训的访谈者用标准化问卷评估了梗死前一年自我报告的日常茶和咖啡消费量。我们研究了室性心律失常的患病率在两个阶段的study.Results：在1912例患者的完整信息在第一阶段，室性心律失常的患病率是16%的戒酒者从茶，11%的中度饮茶者（每周<14杯），和14%的重度饮茶者（每周≥14杯）（P同质性= 0.03）。在第二阶段具有可比信息的1791例患者中，相应的患病率分别为11%、8%和8%（p = 0.06）。当这些阶段合并时，中度饮茶者中VA的调整优势比为0.7（95%置信区间，0.6-0.9），重度饮茶者中为0.9（95%置信区间，0.7-1.2）。室性心动过速和室颤的结果相似。相反，随着咖啡摄入量的增加，VA的风险更高（每周>14杯的比值比为1.3; 95%置信区间为1.0-1.7; p趋势为0.02）。结论：在急性心肌梗死住院患者中，适度的茶摄入量与较低的室性心律失常患病率相关，咖啡摄入量越高，室性心律失常患病率越高。如果与茶摄入量的关联得到证实，它可能会提出预防缺血相关心律失常的新方法。
Background:Tea consumption is associated with lower post-infarct mortality among patients with acute myocardial infarction. We previously found preliminary evidence that tea consumption may also be associated with lower risk of infarct-related ventricular arrhythmias.Methods:Between 1989 and 1996, 3882 subjects with AMI were enrolled in the two phases of the Determinants of Myocardial Infarction Onset Study a median of four days after admission. Trained interviewers assessed self-reported usual tea and coffee consumption during the year prior to infarction with a standardized questionnaire. We examined the prevalence of ventricular arrhythmias in the two phases of the study separately and together.Results:Among the 1912 patients with complete information in the first phase, the prevalence of ventricular arrhythmias was 16% among abstainers from tea, 11% among moderate tea drinkers (<14 cups per week), and 14% among heavier tea drinkers (≥14 cups per week) (p homogeneity = 0.03). Among the 1791 patients with comparable information in the second phase, the corresponding prevalence rates were 11%, 8%, and 8%, respectively (p = 0.06). When the phases were combined, the adjusted odds ratios for VA were 0.7 (95% confidence interval, 0.6–0.9) among moderate tea drinkers and 0.9 (95% confidence interval, 0.7–1.2) among heavier tea drinkers. The findings were of similar direction for both ventricular tachycardia and fibrillation. In contrast, there was higher risk of VA with increasing coffee intake (odds ratio for >14 cups per week 1.3; 95% confidence interval, 1.0–1.7; p trend 0.02).Conclusions:Moderate tea intake is associated with a lower prevalence, and higher coffee intake with a slightly higher prevalence, of ventricular arrhythmias among patients hospitalized with acute myocardial infarction. If the association with tea intake is confirmed, it may suggest new approaches to prevention of ischemia-related arrhythmias.