Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
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DOI：
10.1007/s12282-009-0113-0
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发表时间：
2010-04-01
期刊：
影响因子：
4
通讯作者：
Iwase, Takuji
中科院分区：
文献类型：
--
作者：
Iwase, Hirotaka;Kurebayashi, Junichi;Iwase, Takuji
背景三阴性乳腺癌（TN）是指雌激素受体（ER）、孕激素受体（PgR）和人表皮生长因子受体2（HER 2）均阴性的乳腺癌亚型。为了阐明TN乳腺癌的特点，日本乳腺癌协会登记委员会的监测数据进行了分析。方法在2004年登记的14,748例病例中，11,705例（79.4%）进行了ER、PgR和HER 2检查。其中ER阳性/PgR阳性/HER 2阴性的绝经后应答型占53.8%，其次为TN型占15.5%。这种癌症被诊断为在一个稍微先进的阶段，并与淋巴结转移阳性的病例比其他亚型。形态学上，TN亚型更常被归类为实性管状癌。激素受体阳性/HER 2阴性亚型中经常发现粘液性、管状或分泌性癌，而TN组中经常发现鳞状细胞癌、梭形细胞癌和伴有骨/软骨化生的化生癌。大汗腺癌在TN组中也很常见。化疗的选择是不是基于受体亚型，但由肿瘤progress.Conclusions的程度，虽然TN类型是类似的基底样乳腺肿瘤，基因表达谱确定，其诊断需要验证的表皮生长因子受体或细胞角蛋白5/6的表达水平的测定。TN型应进一步检查免疫组化特征和分析预后的细节在这个队列。
Background Triple negative (TN) breast cancer is defined as a subtype that is negative for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2). To clarify the characteristics of TN breast cancer, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed.Method Of 14,748 cases registered in 2004, 11,705 (79.4%) were examined for ER, PgR, and HER2. Of these, the most prevalent (53.8%) was a hormone-responsive subtype with ER positive/PgR positive/HER2 negative, followed by TN subtype (15.5%).Results The proportion of postmenopausal patients was relatively high in the TN subtype. This cancer was diagnosed at a slightly advanced stage and with more cases positive for lymph node metastases than other subtypes. Morphologically, the TN subtype was more frequently classified as solid-tubular carcinoma. Mucinous, tubular, or secretary carcinomas were frequently found in the hormone receptor positive/HER2 negative subtype, while squamous cell carcinoma, spindle cell carcinoma, and metaplastic carcinoma with bone/cartilage metaplasia were very frequently found in the TN group. Apocrine carcinoma was also found very frequently in the TN group. Selection of chemotherapy was not based on receptor subtypes, but was determined by the degree of tumor progression.Conclusions Although TN types are similar to basal-like breast tumor, as determined by gene profiling, their diagnosis needs verification by determination of the level of epidermal growth factor receptor or cytokeratin 5/6 expression. TN type should be examined further for immunohistochemical features and analyzed for prognostic details in this cohort.