Phylogenetic methods come of age: Testing hypotheses in an evolutionary context
Phylogenetic methods come of age: Testing hypotheses in an evolutionary context
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DOI：
10.1126/science.276.5310.227
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发表时间：
1997-04-11
期刊：
影响因子：
56.9
通讯作者：
Rannala, B
中科院分区：
文献类型：
--
作者：
Huelsenbeck, JP;Rannala, B
随着DNA测序的自动化和有效的计算机程序的可用性，使用分子系统发生学来研究进化问题已经变得司空见惯。计算机模拟和似然比检验在进化假说中的应用代表了这一领域最近的方法学发展。似然比检验使生物学家能够解决进化生物学中许多过去难以解决的问题，例如宿主-寄生虫系统是否是共物种形成的，以及DNA取代模型是否足以解释观察到的序列。
The use of molecular phylogenies to examine evolutionary questions has become commonplace with the automation of DNA sequencing and the availability of efficient computer programs to perform phylogenetic analyses. The application of computer simulation and likelihood ratio tests to evolutionary hypotheses represents a recent methodological development in this field. Likelihood ratio tests have enabled biologists to address many questions in evolutionary biology that have been difficult td resolve in the past, such as whether host-parasite systems are cospeciating and whether models of DNA substitution adequately explain observed sequences.