Fear Learning Enhances Prefrontal Cortical Suppression of Auditory Thalamic Inputs to the Amygdala in Adults, but Not Adolescents
Fear Learning Enhances Prefrontal Cortical Suppression of Auditory Thalamic Inputs to the Amygdala in Adults, but Not Adolescents
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DOI：
10.3390/ijms21083008
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发表时间：
2020-04-01
影响因子：
5.6
通讯作者：
Rosenkranz, J. Amiel
中科院分区：
文献类型：
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作者：
Ferrara, Nicole C.;Mrackova, Eliska;Rosenkranz, J. Amiel
青春期的特点是更容易患上与恐惧和焦虑有关的疾病。青少年也表现出升高的恐惧反应和厌恶学习，这是抵抗行为干预，这可能与改变电路支持恐惧学习。这些特征与正在进行的青少年内侧前额叶皮层（PFC）向基底外侧杏仁核（BLA）的输入的发展有关，该输入调节神经活动并有助于改善恐惧反应。在这里，我们测试的假设，PFC抑制的BLA恐惧学习的程度是在成年人比青少年更大，使用麻醉在体内录音测量局部场电位（LFPs）诱发的PFC或听觉丘脑（MgN）输入BLA的刺激。我们发现，BLA LFPs诱发的刺激MgN输入增强成人恐惧条件反射。恐惧条件反射还导致减少BLA LFPs的总和诱发PFC列车刺激，并增加PFC抑制MgN输入的能力。这些数据表明，恐惧条件反射招聘额外的抑制能力PFC输入BLA在成年人中，但这种能力是较弱的青少年。这些结果提供了深入了解PFC输入的发展可能与年龄差异的记忆保持和持久性以下厌恶学习。
Adolescence is characterized by increased susceptibility to the development of fear- and anxiety-related disorders. Adolescents also show elevated fear responding and aversive learning that is resistant to behavioral interventions, which may be related to alterations in the circuitry supporting fear learning. These features are linked to ongoing adolescent development of medial prefrontal cortical (PFC) inputs to the basolateral amygdala (BLA) that regulate neural activity and contribute to the refinement of fear responses. Here, we tested the hypothesis that the extent of PFC inhibition of the BLA following fear learning is greater in adults than in adolescents, using anesthetized in vivo recordings to measure local field potentials (LFPs) evoked by stimulation of PFC or auditory thalamic (MgN) inputs to BLA. We found that BLA LFPs evoked by stimulation of MgN inputs were enhanced in adults following fear conditioning. Fear conditioning also led to reduced summation of BLA LFPs evoked in response to PFC train stimulation, and increased the capacity of PFC inhibition of MgN inputs in adults. These data suggest that fear conditioning recruits additional inhibitory capacity by PFC inputs to BLA in adults, but that this capacity is weaker in adolescents. These results provide insight into how the development of PFC inputs may relate to age differences in memory retention and persistence following aversive learning.