Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy
Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy
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DOI：
10.1111/j.1600-0463.2008.01025.x
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发表时间：
2008-07-01
期刊：
影响因子：
2.8
通讯作者：
Indraccolo, Stefano
中科院分区：
文献类型：
--
作者：
Favaro, Elena;Amadori, Alberto;Indraccolo, Stefano
血管生成在休眠微转移生长现象中发挥着重要作用，因为血管向肿瘤微环境输送氧气和营养物质。然而，除了这种喂养功能之外，越来越多的证据表明，内皮细胞——也许还有微环境的其他细胞成分——可以向肿瘤细胞传达正信号和负信号。异质细胞类型之间的这种串扰可能对癌细胞行为的调节很重要。在血管生成过程中招募的正常细胞，或被癌细胞释放的可溶性产物吸引到未来的转移部位，已被证明可以创造有利于肿瘤细胞增殖和存活的生态位。此外，在炎症期间可能发生的外源性血管生成峰值之后，相同的机制可能导致植入组织内的血管生成不良的肿瘤细胞重新激活。在这篇综述中，我们讨论了这一假设对我们理解肿瘤休眠现象的可能影响。
Angiogenesis plays an established role in the phenomenon of growth of dormant micrometasis, because blood vessels deliver oxygen and nutrients to the tumor microenvironment. In addition to this feeding function, however, there is accumulating evidence suggesting that endothelial cells - and perhaps other cellular components of the microenvironment - could communicate both positive and negative signals to tumor cells. This cross-talk between heterogenous cell types could turn out to be important in the regulaiton of cancer cell behavior. Normal cells recruited during the agiogenic process, or attracted to future sites of metastasis by soluble products released by cancer cells, have been shown to create a niche favorable to tumor cell proliferation and survival. In addition, following an exogenous angiogenic spike, as may occur during inflammation, the same mechanisms couls lead to re-activation of poorly angiogenic tumor cells seeded intio tissues. In this review, we discuss the possible implications of this hypothesis for our understanding of the phenomenon of tumor dormancy.