Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
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DOI：
10.1016/s1074-7613(00)00009-1
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发表时间：
2000-07-01
期刊：
影响因子：
32.4
通讯作者：
Bevan, MJ
中科院分区：
文献类型：
--
作者：
Deftos, ML;Huang, E;Bevan, MJ
Notch蛋白调节许多发育过程。 Notch1在胸腺细胞上高度表达，但其在调节其发育中的作用尚不清楚。我们表明，CD4（+）CD8（+）双阳性胸腺细胞中Notch1信号的激活促进了CD4（+）和CD8（+）单个阳性胸腺细胞的成熟，并且在T细胞受体之间没有相互作用的情况下会发生这种情况和在胸腺上皮细胞上表达的MHC分子。我们还鉴定了几个在T细胞中由Notch1转录调控的基因，并表明它们在成熟过程中被上调为两个阳性谱系。这些观察结果表明，Notch1信号传导在促进CD4和CD8 T细胞谱系中的成熟方面起作用。
Notch proteins regulate many developmental processes. Notch1 is highly expressed on thymocytes, but its role in regulating their development is not known. We show that activation of Notch1 signaling in CD4(+)CD8(+) double positive thymocytes promotes the maturation of both CD4(+) and CD8(+) single positive thymocytes and that this occurs in the absence of interactions between the T cell receptor and MHC molecules expressed on thymic epithelial cells. We have also identified several genes that are transcriptionally regulated by Notch1 in T cells and show that they are upregulated during maturation into both single positive lineages. These observations suggest that Notch1 signaling plays a role in promoting maturation into both the CD4 and CD8 T cell lineages.