Assessment of Global Liver Blood Flow With Quantitative Dynamic Contrast-Enhanced Ultrasound
Assessment of Global Liver Blood Flow With Quantitative Dynamic Contrast-Enhanced Ultrasound
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DOI：
10.7863/jum.2011.30.3.379
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发表时间：
2011-03-01
影响因子：
2.3
通讯作者：
Leen, Edward L. S.
中科院分区：
文献类型：
--
作者：
Gauthier, Thomas P.;Wasan, Harpreet S.;Leen, Edward L. S.
目的-这项研究评估了潜在的定量分析对比剂团动力学，以反映全球liver bloodflow. Methods-一个动态对比增强超声流量幻影开发。蠕动泵建立恒定体积流量，范围为16.5 - 49.5 mL/min（2 mm管）和85.5 - 256.5 mL/min（5 mm管）。在团注2个剂量的造影剂后，在用于特定采集的管的横截面上绘制感兴趣区域;从时间-强度曲线导出上升时间、峰值强度和洗入斜率。20例健康志愿者和25例活检证实的结直肠肝转移患者进行了动态超声造影扫描。上升时间、峰值强度和洗入斜率来自肝动脉和门静脉时间-强度曲线。肝动脉/门静脉的参数的比率也calculated.Results-In体外实验中，上升时间减少，而峰值强度和洗入斜率增加的体积流量为两个管直径和对比剂团体积。在临床研究中，与健康志愿者相比，结直肠肝转移患者的肝动脉上升时间降低，但门静脉上升，峰值强度和洗入斜率在肝动脉升高，但在门静脉降低，尽管没有统计学显著性。与健康志愿者相比，结直肠癌肝转移患者的肝动脉血流量增加，门静脉血流量减少，或两者兼而有之。只有3个肝动脉/门静脉比率的参数达到统计学意义，区分健康志愿者与结直肠癌肝转移患者（P <0.05）。它们可能具有快速和简单评估肝脏血流动力学改变的潜力。
Objectives-This study assessed the potential of quantitative analysis of contrast bolus kinetics to reflect global liver blood flow.Methods-A dynamic contrast-enhanced ultrasound flow phantom was developed. A peristaltic pump established constant volume flow ranging between 16.5 and 49.5 mL/min (2-mm tube) and 85.5 and 256.5 mL/min (5-mm tube). After bolus injection of 2 doses of a contrast agent, a region of interest was drawn over the cross section of the tube used for a particular acquisition; the rise time, peak intensity, and wash-in slope were derived from time-intensity curves. Twenty healthy volunteers and 25 patients with biopsy-proven colorectal liver metastases were scanned with dynamic contrast-enhanced ultrasound. The rise time, peak intensity, and wash-in slope were derived from hepatic artery and portal vein time-intensity curves. Hepatic artery/portal vein ratios of the parameters were also calculated.Results-In the in vitro experiment, the rise time decreased while the peak intensity and wash-in slope increased with increasing volume flow for both tube diameters and contrast bolus volumes. In the clinical study, the rise time was lowered in the hepatic artery but elevated in the portal vein, and the peak intensity and wash-in slope were elevated in the hepatic artery but lowered in the portal vein in patients with colorectal liver metastases compared with healthy volunteers, although not in a statistically significant manner. This finding was consistent with an increase in hepatic artery blood flow, a decrease in portal vein blood flow, or both in patients with colorectal liver metastases compared with healthy volunteers. Only the 3 hepatic artery/portal vein ratios of the parameters achieved statistical significance in differentiating healthy volunteers from patients with colorectal liver metastases (P < .05).Conclusions-Surrogate measurements of liver blood flow may be derived from quantitative analysis of dynamic contrast-enhanced ultrasound studies. They may have potential for quick and easy assessment of altered hepatic hemodynamics.