Effect of zinc supplementation on malaria and other causes of morbidity in west African children:: randomised double blind placebo controlled trial
Effect of zinc supplementation on malaria and other causes of morbidity in west African children:: randomised double blind placebo controlled trial
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DOI：
10.1136/bmj.322.7302.1567
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发表时间：
2001-06-30
影响因子：
105.7
通讯作者：
Garenne, M
中科院分区：
文献类型：
--
作者：
Müller, O;Becher, H;Garenne, M
目的研究补锌对西非疟疾全流行区幼儿疟疾及其他病因的影响。设计随机、双盲、安慰剂对照的疗效试验。在布基纳法索西北部农村的18个村庄进行。685完成了试验。干预补充锌（12.5毫克硫酸锌）或安慰剂，每周6天，持续6个月。主要结果测量主要结果是症状性恶性疟疾的发病率。次要结果是疟疾发作的严重程度、疟疾寄生虫患病率、平均寄生虫密度、平均红细胞压积、其他疾病患病率和全因死亡率。（定义为温度大于或等于37.5 ℃，寄生虫大于或等于5000个/穆尔）为1.7，99.7%为恶性疟原虫感染。锌组和安慰剂组在恶性疟疾发病率（相对危险度0.98，95%置信区间0.80 ~ 1.11）、疟疾发作期间的平均温度和平均寄生虫密度方面没有差异，在横断面调查期间的疟疾寄生虫率、平均寄生虫密度和平均红细胞压积方面也没有差异。补锌与腹泻患病率降低显著相关（0.87，0.79至0.95）。与给予安慰剂的儿童相比，给予锌的儿童的全因死亡率无显着降低（5比12，P= 0.1）。结论补锌对西非农村儿童恶性疟疾的发病率没有影响，但确实降低了腹泻相关的发病率。
Objective To study the effects of zinc supplementation on malaria and other causes of morbidity in young children living in an area holoendemic for malaria in west Africa.Design Randomised, double blind, placebo controlled efficacy trial.Setting 18 villages in rural northwestern Burkina Faso.Participants 709 children were enrolled; 685 completed the trial.Intervention Supplementation with zinc (12.5 mg zinc sulphate) or placebo daily for six days a week for six months.Main outcome measures The primary outcome was the incidence of symptomatic falciparum malaria. Secondary outcomes were die severity of malaria episodes, prevalence of malaria parasites, mean parasite densities, mean packed cell volume, prevalence of other morbidity, and all cause mortality.Results The mean number of malaria episodes per child (defined as a temperature greater than or equal to 37.5 degreesC with greater than or equal to 5000 parasites/mul) was 1.7, 99.7% due to infection with Plasmodium falciparum. No difference was found between the zinc and placebo groups in the incidence of falciparum malaria (relative risk 0.98, 95% confidence interval 0.80 to 1.11), mean temperature, and mean parasite densities during malaria episodes, nor in malaria parasite rates, mean parasite densities, and mean packed cell volume during cross sectional surveys. Zinc supplementation was significantly associated with a reduced prevalence of diarrhoea (0.87, 0.79 to 0.95). All cause mortality was non-significantly lower in children given zinc compared with those given placebo (5 v 12, P= 0.1).Conclusions Zinc supplementation has no effect on morbidity from falciparum malaria in children in rural west Africa, but it does reduce morbidity associated with diarrhoea.