Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
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DOI：
10.1016/s0968-0004(96)20026-x
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发表时间：
1996-12-01
影响因子：
13.8
通讯作者：
Ferrell, JE
中科院分区：
文献类型：
--
作者：
Ferrell, JE
最近的实验工作表明，丝裂原活化蛋白（MAP）激酶级联可以将分级输入转化为开关输出。因此，级联可以过滤掉噪声（强度或持续时间不足的信号），并且仍然对超阈值刺激做出果断反应。在这里，我们探索可能是在这种行为的根源的生化机制。
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.