Paternity following treatment for testicular cancer
Paternity following treatment for testicular cancer
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DOI：
10.1093/jnci/dji339
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发表时间：
2005-11-02
影响因子：
10.3
通讯作者：
Dahl, O
中科院分区：
文献类型：
--
作者：
Brydoy, M;Fosså, SD;Dahl, O
背景资料：对接受睾丸癌治疗的男性生育力的研究主要针对血清促卵泡激素水平和精子参数。我们评估了睾丸癌长期幸存者治疗后的亲子关系。研究方法：1980年至1994年期间在挪威接受单侧睾丸癌治疗的男性（n = 1814）被邀请参加1998年至2002年的全国多中心随访调查。根据睾丸切除术后接受的治疗，将参与者分为五组，包括复发时的治疗（监测、腹膜后淋巴结清扫、放疗、低剂量化疗[即， 850 mg顺铂]）。考克斯比例风险分析用于评估治疗后亲子关系的预测因素。统计检验是双侧的。结果：共有1433名男性可评估，其中827人在诊断时是父亲。554名男性尝试了治疗后受孕，其中在不使用冷冻精液的情况下，15年的总体精算治疗后父权率为71%（95%置信区间[CI] = 66%至75%）。高剂量化疗组的发生率为48%（95%CI = 30%-69%），监测组为92%（95%CI = 78%-98%）（P
Background: Studies of fertility in men treated for testicular cancer have mainly addressed serum follicle-stimulating hormone levels and sperm parameters. We assessed post-treatment paternity among long-term survivors of testicular cancer. Methods: Men (n = 1814) who had been treated for unilateral testicular cancer in Norway during 1980 through 1994 were invited to participate in a national multi-center follow-up survey in 1998 through 2002. The participants were allocated to five groups according to the treatment received after orchiectomy, including treatment at relapse (surveillance, retroperitoneal lymph node dissection, radiotherapy, low-dose chemotherapy [i.e., 850 mg cisplatin]). Cox proportional hazards analysis was used to assess predictive factors for post-treatment paternity. Statistical tests were two-sided. Results: A total of 1433 men were assessable, of whom 827 were fathers at diagnosis. Posttreatment conception was attempted by 554 men, among whom the overall 15-year actuarial post-treatment paternity rate was 71% (95% confidence interval [CI] = 66% to 75%) without the use of cryopreserved semen. This rate ranged from 48% (95% CI = 30% to 69%) in the high-dose chemotherapy group to 92% (95% CI = 78% to 98%) in the surveillance group (P