Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications
Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications
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DOI：
10.1007/s10654-018-0442-4
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发表时间：
2019-01-01
影响因子：
13.6
通讯作者：
Strongman, Helen
中科院分区：
文献类型：
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作者：
Padmanabhan, Shivani;Carty, Lucy;Strongman, Helen
记录链接越来越多地用于扩大公共卫生研究的可用信息。了解记录关联方法以及相关的优势和局限性对于关联数据的可靠分析和解释非常重要。在这里，我们描述了临床实践研究数据链（CPRD）所使用的方法，将初级保健数据与其他患者水平的数据集，以及这种方法对CPRD数据分析的潜在影响。全科电子健康记录软件提供商分别向CPRD提交去识别数据，向NHS Digital提交患者标识符，不包括选择退出贡献数据的患者。外部数据集的数据保管人还将患者标识符发送到NHS Digital。NHS Digital使用标识符使用8阶段确定性方法来链接数据集。CPRD随后收到一个去识别的链接队列文件，并向研究人员提供匿名链接数据和元数据，详细说明链接过程。这种方法已被用于生成常规的初级保健相关数据集，包括来自医院事件统计，国家统计局和国家癌症登记和分析服务的数据。10.6 2018年6月，来自411家英国全科诊所的100万（M）例患者被纳入记录链接。910万（86%）患者具有研究质量，其中800万（88%）患者具有有效的NHS编号，符合CPRD标准链接数据集发布的链接条件。将《残疾人权利公约》的数据与其他来源联系起来，可扩大研究的范围和有效性。这份手稿，连同匹配强度和链接资格生成的元数据，可用于通知研究设计和探索潜在的链接相关的选择和错误分类的偏见。
Record linkage is increasingly used to expand the information available for public health research. An understanding of record linkage methods and the relevant strengths and limitations is important for robust analysis and interpretation of linked data. Here, we describe the approach used by Clinical Practice Research Datalink (CPRD) to link primary care data to other patient level datasets, and the potential implications of this approach for CPRD data analysis. General practice electronic health record software providers separately submit de-identified data to CPRD and patient identifiers to NHS Digital, excluding patients who have opted-out from contributing data. Data custodians for external datasets also send patient identifiers to NHS Digital. NHS Digital uses identifiers to link the datasets using an 8-stage deterministic methodology. CPRD subsequently receives a de-identified linked cohort file and provides researchers with anonymised linked data and metadata detailing the linkage process. This methodology has been used to generate routine primary care linked datasets, including data from Hospital Episode Statistics, Office for National Statistics and National Cancer Registration and Analysis Service. 10.6million (M) patients from 411 English general practices were included in record linkage in June 2018. 9.1M (86%) patients were of research quality, of which 8.0M (88%) had a valid NHS number and were eligible for linkage in the CPRD standard linked dataset release. Linking CPRD data to other sources improves the range and validity of research studies. This manuscript, together with metadata generated on match strength and linkage eligibility, can be used to inform study design and explore potential linkage-related selection and misclassification biases.