Dopaminergic medication boosts action-effect binding in Parkinson's disease
Dopaminergic medication boosts action-effect binding in Parkinson's disease
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DOI：
10.1016/j.neuropsychologia.2009.12.014
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发表时间：
2010-03-01
期刊：
影响因子：
2.6
通讯作者：
Haggard, Patrick
中科院分区：
文献类型：
--
作者：
Moore, James W.;Schneider, Susanne A.;Haggard, Patrick
帕金森病（PD）是一种影响自主运动控制的神经退行性疾病。然而，很少有人知道PD患者的自愿行动的经验。行动经验的一个关键组成部分是控制自己的行动，并通过他们，外部事件的感觉。在健康的个体中，这种能动感（SoA）与主观的时间压缩有关，这样的行为及其影响被认为是在时间上联系在一起的。这种作用-效果结合提供了SoA的间接测量。9名PD患者和年龄匹配的对照判断自愿行动的时间和听觉效果（音调）的行动。结果的模式类似于以前的研究，与感知时间的行动显示出转向随后的语气，相对于基线条件，涉及没有音调的行动。同样，感知到的音调的时间显示出对前面的动作，导致的音调，相对于一个基线条件，只涉及音调的转变。这些患者接受了多巴胺能药物治疗和停药的测试。与对照组相比，停药的PD患者的作用-效应结合无显著变化。相反，药物治疗的PD患者表现出显着增加的作用-效果结合相对于他们自己的表现关闭药物。增加多巴胺的可用性加强了行动与外部事件之间的关联体验，增强了代理感。这些结果揭示了多巴胺的贡献的经验，工具的行动，也对冲动控制障碍和精神病的药物PD患者。(C)2009爱思唯尔有限公司保留所有权利。
Parkinson's disease (PD) is a neurodegenerative disorder affecting voluntary motor control. However, little is known about the experience of voluntary action in PD patients. A key component of action experience is the feeling of controlling one's own actions, and through them, external events. In healthy individuals this sense of agency (SoA) is associated with a subjective compression of time, such that actions and their effects are perceived as bound together across time. This action-effect binding provides an indirect measure of SoA. Nine PD patients and age-matched controls judged the time of voluntary actions and of an auditory effect (a tone) of the action. The pattern of results resembled previous studies, with the perceived time of actions showing a shift towards the subsequent tone, relative to a baseline condition involving actions without tones. Similarly, the perceived times of tones showed a shift towards the preceding action that caused the tone, relative to a baseline condition involving tones only. The patients were tested both on and off dopaminergic medication. PD patients off medication showed no significant change in action-effect binding relative to controls. Conversely, PD patients on medication showed a significant increase in action-effect binding relative to their own performance off medication. Increased availability of dopamine strengthened the experience of association between actions and external events, enhancing the sense of agency. These results shed light on the contribution of dopamine to the experience of instrumental action, and also on impulse control disorders and psychosis in medicated PD patients. (C) 2009 Elsevier Ltd. All rights reserved.