Role of Inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms.
Role of Inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms.
复制标题
炎症在人类疲劳中的作用：多维评估和潜在神经元机制的相关性。
DOI：
10.3389/fimmu.2017.00021
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发表时间：
2017
影响因子：
7.3
通讯作者：
Lasselin J
中科院分区：
文献类型：
--
作者：
Karshikoff B;Sundelin T;Lasselin J
在各种医疗条件下，疲劳是一种高度致残的症状。虽然炎症被认为是疲劳形成的潜在因素，但其潜在的机制仍然知之甚少。在这篇综述中，我们建议，考虑到中枢性疲劳的多维特征，更好地评估中枢性疲劳有助于阐明炎症在疲劳发展中的作用和机制。对中枢疲劳的特征进行了描述，并对目前描述炎症和疲劳在不同医疗条件下的联系的证据进行了综述。此外，炎症对可能涉及不同疲劳维度的特定神经元过程的影响也被描述。我们建议在未来炎症性疲劳的研究中对疲劳的多维方面进行评估，这将有助于开发有效的治疗干预措施。
Fatigue is a highly disabling symptom in various medical conditions. While inflammation has been suggested as a potential contributor to the development of fatigue, underlying mechanisms remain poorly understood. In this review, we propose that a better assessment of central fatigue, taking into account its multidimensional features, could help elucidate the role and mechanisms of inflammation in fatigue development. A description of the features of central fatigue is provided, and the current evidence describing the association between inflammation and fatigue in various medical conditions is reviewed. Additionally, the effect of inflammation on specific neuronal processes that may be involved in distinct fatigue dimensions is described. We suggest that the multidimensional aspects of fatigue should be assessed in future studies of inflammation-induced fatigue and that this would benefit the development of effective therapeutic interventions.