Paraneoplastic cerebellar disorders.
Paraneoplastic cerebellar disorders.
复制标题
副肿瘤性小脑疾病。
DOI：
10.1016/s0194-59989570311-x
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Baloh,RW
中科院分区：
文献类型：
--
作者：
Baloh,RW
副肿瘤性小脑变性典型地开始于躯干和四肢的快速进行性共济失调。在大约一半的患者中发现了抗神经元抗体。最特异的自身抗体是在妇科肿瘤患者中发现的抗浦肯野细胞抗体。即使在肿瘤被切除后，大多数患者的小脑缺陷仍然存在。
Paraneoplastic cerebellar degeneration typically begins with rapidly progressive ataxia of the trunk and extremities. Antineuronal antibodies are found in about half the patients. The most specific autoantibody is an anti-Purkinje cell antibody found in women with gynecologic tumors. Even after the tumor is removed, the cerebellar deficit persists in most patients.