Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children.
Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children.
复制标题
城市少数民族儿童呼出一氧化氮分数与哮喘发病率的关系。
DOI：
10.1080/02770903.2022.2073549
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Rastogi,Deepa
中科院分区：
文献类型：
--
作者：
Chen,Laura;Agalliu,Ilir;Roth,Adam;Rastogi,Deepa
ObjectiveFractional exhaled nitric oxide (FeNO) is a well-established measure of allergic airway inflammation and possible useful adjunct disease management tool. We investigated the association of baseline and follow-up FeNO measurements with disease burden in minority children with persistent asthma.MethodsA retrospective chart review was conducted on 352 African American and Hispanic children seen at an urban Asthma Center in Bronx, NY. Demographic, clinical characteristics, and pulmonary function tests (PFTs) were compared between children with low, intermediate, and high baseline FeNO levels. Among 95 children with subsequent follow up visits, associations of change in FeNO with demographics, clinical characteristics, and PFTs were examined using mixed effects linear regression models.ResultsA higher proportion of children with intermediate (54%) and high FeNO (58%) levels had lower airways obstruction compared to those with low FeNO levels (33%). Children with intermediate FeNO levels had more annual hospitalizations (2.8 ± 6.2) compared to those with low and high FeNO levels (1.3 ± 2.8 and 1.3 ± 2.5). These associations did not differ between ethnicities. An increase in FeNO over time was associated with higher BMI z-scores (β = 6.2, 95% CI: 1.0 to 11.4) and two or more hospitalizations in the past year (β = 16.1, 95% CI: 1.5 to 30.8).ConclusionsIntermediate and high FeNO levels are associated with lower airways obstruction and hospitalizations. Initial and serial FeNO measurements can be a useful adjunctive tool in identifying asthma-related morbidity in urban African American and Hispanic children.
