Impairments in glycemic control during Eastbound transatlantic travel in healthy adults.
Impairments in glycemic control during Eastbound transatlantic travel in healthy adults.
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DOI：
10.1093/sleepadvances/zpac009
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发表时间：
2022
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反复出现的昼夜节律失调会损害葡萄糖耐量。然而，与旅行和时差相关的昼夜节律失调是否会损害自由生活人群的血糖稳态尚不清楚。本研究的目的是检查健康男性和女性在东行跨大西洋旅行一周期间的血糖控制情况。七名健康参与者（5 名女性；年龄：35.6 ± 2.5 岁，BMI：23.9 ± 2.4 m/kg2）从美国科罗拉多州 (GMT-7) 前往欧洲（GMT 和 GMT+1），并在旅行前、旅行期间和旅行后 8-14 天佩戴连续血糖监测仪 (Freestyle Libre Pro)。总结 24 小时内、白天和夜间的血糖控制指数。在整个旅行期间，平均血糖、峰值血糖和高血糖时间相对于基线水平呈线性增加。每 24 小时平均葡萄糖浓度上升 1.03 mg/dL (95% CI: 0.34, 1.74)，高血糖持续时间增加 17 分钟 (95% CI: 5.5, 28.6)。 24小时血糖的增加主要是由日间参数的增加驱动的，其中平均血糖增加（每天0.72 mg/dL，[95% CI：-0.1，1.5]）和高血糖持续时间（每天13.2分钟[95% CI：4.3，22.1]）。平均血糖每晚增加，但峰值血糖或高血糖时间不增加（每晚 0.7 mg/dL [95% CI: 0.2, 1.2]）。东行跨大西洋旅行导致 24 小时、白天和夜间的血糖指标逐渐恶化。未来有必要对代谢紊乱患者时差期间的血糖控制进行研究。没有任何
Repeated bouts of circadian misalignment impair glucose tolerance. However, whether circadian misalignment associated with travel and jet lag impair glucose homeostasis in a free-living population is not known. The goal of the present study was to examine glycemic control during one week of Eastbound transatlantic travel in healthy men and women. Seven healthy participants (5 women; age: 35.6 ± 2.5 years, BMI: 23.9 ± 2.4 m/kg2) traveled from Colorado, USA (GMT-7) to Europe (GMT and GMT+1) and wore a continuous glucose monitor (Freestyle Libre Pro) for 8–14 days before, during, and after travel. Indices of glycemic control were summarized over 24-hour periods and by day and night. Mean glucose, peak glucose, and time spent in hyperglycemia increased linearly throughout the travel period relative to baseline levels. Mean glucose concentrations rose 1.03 mg/dL (95% CI: 0.34, 1.74) and duration of hyperglycemia increased by 17 min (95% CI: 5.5, 28.6) each 24-hour period. Increases in 24-hour glucose were primarily driven by increases in daytime parameters with rising mean glucose (0.72 mg/dL per day, [95% CI: −0.1, 1.5]) and duration of hyperglycemia (13.2 min per day [95% CI: 4.3, 22.1]). Mean glucose, but not peak glucose or time spent in hyperglycemia, increased each night (0.7 mg/dL per night [95% CI: 0.2, 1.2]). Eastbound transatlantic travel induced a progressive worsening of glucose metrics during 24-hour, day, and night periods. Future research on managing glycemic control during jet lag in people with metabolic disorders is warranted. None