Studies on opioid receptor selectivity of beta-endorphin antagonists.
Studies on opioid receptor selectivity of beta-endorphin antagonists.
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β-内啡肽拮抗剂阿片受体选择性的研究。
DOI：
10.1111/j.1399-3011.1985.tb03188.x
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Li,CH
中科院分区：
文献类型：
--
作者：
HammondsJr,RG;Li,CH
使用部分选择性结合试验评估了拮抗β-内啡肽（β-EP）诱导镇痛的几种β-EP类似物的阿片受体选择性。尽管在这些试验中β-EP的表观亲和解离常数在0.2至360 nm之间变化，但β-EP拮抗剂相对于β-EP的效力基本保持不变。受体亲和力的差异不太可能解释这些类似物在体内的拮抗剂特性。
Opioid receptor selectivity of several β‐endorphin (β‐EP) analogs which antagonize β‐EP‐induced analgesia has been assessed using partially selective binding assays. Although the apparent affinity dissociation constant of β‐EP in these assays varies from 0.2 to 360 nm, the potency of β‐EP antagonists relative to β‐EP remains largely unchanged. It is unlikely that differences in receptor affinities can account for the antagonist properties of these analogs in vivo.