A MAGNETIZATION-TRANSFER IMAGING STUDY OF NORMAL-APPEARING WHITE-MATTER IN MULTIPLE-SCLEROSIS
A MAGNETIZATION-TRANSFER IMAGING STUDY OF NORMAL-APPEARING WHITE-MATTER IN MULTIPLE-SCLEROSIS
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DOI：
10.1212/wnl.45.3.478
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发表时间：
1995-03-01
期刊：
影响因子：
9.9
通讯作者：
COMI, G
中科院分区：
文献类型：
--
作者：
FILIPPI, M;CAMPI, A;COMI, G
我们试图确定在多发性硬化症（MS）残疾的发展中，外观正常的白色物质（NAWM）的细微变化的作用。27名临床确诊的MS患者，无论是复发缓解或慢性进展过程和10个性别和年龄匹配的对照组进入研究。对于每个病人和对照组，我们研究了两个NAWM领域的额叶磁化传递成像（MTI）。对于患者，我们还计算了从常规MRI可见的“孤立”病变逐渐远离的NAWM的三个连续区域的MT比率（MTRs）。MS患者的额叶NAWM的平均MTR低于对照组的额叶白色物质（p = 0.02）。孤立性病变邻近NAWM的MTR随其与皮质灰质的距离增加而增加（p = 0.04）。这种模式是典型的慢性进展型MS患者的MTR在前两个区域的NAWM邻近病变低于复发缓解型MS患者的相同区域。这项研究证实，有MS患者的NAWM的改变，并表明这种变化可能与MS的残疾。
We attempted to define the role of subtle changes in the normal-appearing white matter (NAWM) in the development of disability in multiple sclerosis (MS). Twenty-seven clinically definite MS patients with either relapsing-remitting or chronic-progressive courses and 10 sex- and age-matched controls entered the study. For each patient and control, we studied two NAWM areas in the frontal lobe with magnetization transfer imaging (MTI). For patients, we also calculated the MT ratios (MTRs) for three contiguous areas of NAWM progressively further from ''isolated'' lesions visible on conventional MRI. Frontal NAWM in MS patients had lower mean MTRs than the frontal white matter of the controls (p = 0.02). MTRs in the NAWM adjacent to isolated lesions increased with distance from them to the cortical gray matter (p = 0.04). This pattern was typical for patients with chronic-progressive MS whose MTRs in the first two regions of NAWM adjacent to lesions were lower than those of the same regions of patients with relapsing-remitting MS. This study confirms that there are alterations in the NAWM of MS patients and suggests that such changes might be relevant to the disability in MS.