Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo)
Histological and immunohistochemical features of histiocytic sarcoma in four domestic ferrets (Mustela putorius furo)
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DOI：
10.1177/1040638715626485
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发表时间：
2016-03-01
影响因子：
1.5
通讯作者：
Nakayama, Hiroyuki
中科院分区：
文献类型：
--
作者：
Thongtharb, Atigan;Uchida, Kazuyuki;Nakayama, Hiroyuki
本文报告四例家貂组织细胞肉瘤。从腹腔脏器（包括脾脏）中获得的肿瘤样本用于组织学检查。显微镜下，界限不清的肿块包含大量圆形至多形细胞，细胞质呈粗空泡状和嗜酸性。通常观察到具有低吞噬活性的奇异的双核肿瘤细胞和多核巨瘤细胞。免疫组化显示，所有病例的肿瘤细胞波形蛋白、人类白细胞抗原-DR、离子钙结合衔接分子-1和溶菌酶均呈阳性，但其中一些缺乏分化簇（CD）163或CD 208表达。手术切除后生存期9天~ 5个月。雪貂的组织细胞肉瘤是一种罕见但高度侵袭性的肿瘤，通常发生在脾脏。
Four cases of histiocytic sarcoma in domestic ferrets (Mustela putorius furo) are described in the present study. Tumor samples obtained from the abdominal viscera, including the spleen, were submitted for histologic examination. Microscopically, poorly demarcated masses contained numerous round- to pleomorphic-shaped cells with coarsely vacuolated and eosinophilic cytoplasm. Bizarre, binucleated tumor cells and multinucleated giant tumor cells with low phagocytic activity were commonly observed. Immunohistochemically, tumor cells in all of the cases were positive for vimentin, human leukocyte antigen-DR, ionized calcium-binding adapter molecule-1, and lysozyme, but some of them lacked cluster of differentiation (CD)163 or CD208 expression. The survival time after surgical resection was 9 days to 5 months. Histiocytic sarcoma in the ferret is a rare, but highly aggressive, tumor commonly found in the spleen.