Effects of peripheral CCK receptor blockade on food intake in rats.
Effects of peripheral CCK receptor blockade on food intake in rats.
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外周 CCK 受体阻断对大鼠食物摄入的影响。
DOI：
10.1152/ajpregu.00176.2003
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Hulce,Martin
中科院分区：
文献类型：
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作者：
Reidelberger,RogerD;Castellanos,DanielA;Hulce,Martin
Type A cholecystokinin receptor (CCKAR) antagonists differing in blood-brain barrier permeability were used to test the hypothesis that satiety is mediated, in part, by CCK action at CCKARs located peripheral to the blood-brain barrier. At dark onset, non-food-deprived rats received a bolus injection of devazepide (2.5 μmol/kg iv), a 3-h infusion of A-70104 (1 or 3 μmol·kg-1·h-1iv), or vehicle either alone or coadministered with a 3-h infusion of CCK-8 (10 nmol·kg-1·h-1iv) or a 2-h intragastric infusion of peptone (1 g/h). Food intake was determined from continuous computer recordings of changes in food bowl weight. Devazepide penetrates the blood-brain barrier; A-70104, the dicyclohexylammonium salt ofNα-3-quinolinoyl-d-Glu-N,N-dipentylamide (A-65186), does not. CCK-8 inhibited 3-h food intake by more than 50% and both A-70104 and devazepide abolished this response. A-70104 and devazepide stimulated food intake and similarly attenuated the anorexic response to intragastric infusion of peptone. Thus endogenous CCK appears to act, in part, at CCKARs peripheral to the blood-brain barrier to inhibit food intake.
