A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group
A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group
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DOI：
10.1002/chem.202300922
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发表时间：
2023-07-24
影响因子：
4.3
通讯作者：
Cuthbertson，James D.
中科院分区：
文献类型：
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作者：
Dhak，Mandeep S.;Arunprasath，Dhanarajan;Cuthbertson，James D.
描述了一种光氧化还原介导的自由基酰胺化扩环序列，该序列能够产生带有保护的氨甲基取代基的全碳四元中心。该方法可应用于以简明的方式产生结构多样的富含SP3的胺衍生物的苯乙烯和未活化的烯烃底物。
A photoredox‐mediated radical amidation ring‐expansion sequence that enables the generation of all‐carbon quaternary centers bearing a protected aminomethyl substituent is described. The methodology can be applied to both styrene and unactivated alkene substrates generating structurally diverse sp3‐rich amine derivatives in a concise manner.