Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine•pyrimidine interruption
Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine•pyrimidine interruption
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DOI：
10.1039/b103743a
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发表时间：
2001-09-21
影响因子：
4.9
通讯作者：
Sun, JS
中科院分区：
文献类型：
--
作者：
Guianvarc'h, D;Benhida, R;Sun, JS
热变性实验已经证实，含有人工核碱基S的寡核苷酸确实与双链DNA形成稳定的三联体，在寡嘌呤序列中表现出嘧啶中断。
Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.