Antibodies to glutamate and aspartate recognize non-endogenous ligands for excitatory amino acid receptors.
Antibodies to glutamate and aspartate recognize non-endogenous ligands for excitatory amino acid receptors.
复制标题
谷氨酸和天冬氨酸抗体识别兴奋性氨基酸受体的非内源性配体。
DOI：
10.1016/0006-8993(90)90848-6
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Rustioni,A
中科院分区：
文献类型：
--
作者：
Petrusz,P;VanEyck,SL;Weinberg,RJ;Rustioni,A
Antisera raised against glutaraldehyde conjugates of glutamate (Glu) and asparate (Asp) with hemocyanin proved highly specific for their respective unconjugated amino acid haptens when tested in immunocytochemical blocking experiments on sections of the rat spinal cord. In addition, immunocytochemical staining by the Glu antiserum was effectively blocked by quisqualate but not by kainate orN-methyl-d-aspartate (NMDA); staining with the Asp antiserum was effectively blocked by kainate, to a lesser extent by quisqualate, and was not affected by NMDA. These results may be explained by assuming that the specific binding regions of the antibodies tested share certain recognition characteristics with endogenous binding sites or receptors for excitatory amino acids and their agonists.
