Pathogenic effects of asbestos.
Pathogenic effects of asbestos.
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石棉的致病作用。
DOI：
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发表时间：
1977
影响因子：
4.6
通讯作者：
I. Selikoff
中科院分区：
文献类型：
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作者：
M. Kannerstein;J. Churg;E. McCaughey;I. Selikoff
本世纪石棉的使用量大幅增加，因此有必要对其致病作用进行深入研究。已经确定肺实质和胸膜纤维化的发生以及肺和胃肠道癌以及胸膜和腹膜间皮瘤的患病率增加。也可能与喉癌有关。间皮瘤与间接职业、家庭和邻里暴露有关，并且有人提出肺癌与低暴露也可能存在类似的相关性。在这些情况下已经证实了肺纤维化和胸膜斑块。石棉纤维的物理特性似乎是其致癌作用的主要因素。细短纤维，尤其是碎片温石棉到达胸膜的能力似乎可以解释石棉相关疾病的许多发病和解剖特征。
The enormous increase in the use of asbestos during this century has necessitated the intensive study of its pathogenic effects. The occurrence of pulmonary parenchymal and pleural fibrosis and an increased prevalence of pulmonary and gastrointestinal carcinoma and of pleural and peritoneal mesothelioma have been established. A relationship, also, to laryngeal carcinoma is probable. Mesothelioma has been associated with indirect occupational, domestic, and neighborhood exposure, and the possibility of a similar correlation of pulmonary carcinoma with low exposure has been suggested. Pulmonary fibrosis and pleural plaques have been demonstrated under these circumstances. The physical characteristics of the asbestos fiber appear to be the principal factors in its carcinogenic action. The ability of fine, short fibers, especially fragmented chrysotile, to reach the pleura would appear to account for many of the pathogenetic and anatomical features of asbestos-related disease.