Mechanisms involved in hematopoietic stem cell aging
Mechanisms involved in hematopoietic stem cell aging
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DOI：
10.1007/s00018-022-04356-5
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发表时间：
2022-08
影响因子：
8
通讯作者：
Takeshi Fujino;S. Asada;S. Goyama;Toshio Kitamura
中科院分区：
文献类型：
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作者：
Takeshi Fujino;S. Asada;S. Goyama;Toshio Kitamura
造血干细胞（HSC）由于内部和外部应激因素，随着时间的推移经历进行性功能衰退，导致造血系统老化。全面了解HSC衰老的分子机制将有助于开发HSC年轻化的新疗法，并预防几种年龄相关疾病和血液恶性肿瘤的发生。这篇综述考虑了HSC老化的一般原因，从细胞内在因素到细胞外在因素。特别是，表观遗传学和炎症已涉及HSC老化，克隆性和肿瘤发生的联系。阐明HSC衰老机制的挑战加速了治疗干预措施的发展，以振兴HSC，衰老研究的主要目标，这些细节也在这篇综述中进行了讨论。
Hematopoietic stem cells (HSCs) undergo progressive functional decline over time due to both internal and external stressors, leading to aging of the hematopoietic system. A comprehensive understanding of the molecular mechanisms underlying HSC aging will be valuable in developing novel therapies for HSC rejuvenation and to prevent the onset of several age-associated diseases and hematological malignancies. This review considers the general causes of HSC aging that range from cell-intrinsic factors to cell-extrinsic factors. In particular, epigenetics and inflammation have been implicated in the linkage of HSC aging, clonality, and oncogenesis. The challenges in clarifying mechanisms of HSC aging have accelerated the development of therapeutic interventions to rejuvenate HSCs, the major goal of aging research; these details are also discussed in this review.