ENERGY-UTILIZATION OF A LOW CARBOHYDRATE DIET FED GENETICALLY OBESE RATS AND MICE
ENERGY-UTILIZATION OF A LOW CARBOHYDRATE DIET FED GENETICALLY OBESE RATS AND MICE
复制标题
DOI：
10.1093/jn/107.2.320
复制
发表时间：
1977-01-01
影响因子：
4.2
通讯作者：
MAYER, J
中科院分区：
文献类型：
--
作者：
THENEN, SW;MAYER, J
遗传肥胖的Zucker大鼠、ob/ob小鼠和非肥胖的窝鼠分别饲喂低碳水化合物（碳水化合物、蛋白质和脂肪分别占能量的2%、48%和50%）和对照（碳水化合物、蛋白质和脂肪分别占能量的60%、19%和21%）的饮食。通过添加D-[U（统一标记）- 14c]葡萄糖、L-[U- 14c]谷氨酸和甘油三-[1-14C]油酸，测量这些饲料中能量成分的氧化，并收集4小时的呼吸二氧化碳。动物对低碳水化合物饮食的反应是氧化更少的葡萄糖和更多的谷氨酸，但这些量与饮食中的碳水化合物和蛋白质组成成比例。相反，当喂食低碳水化合物饮食时，动物氧化三油酸甘油的量和百分比都更高。肥胖的Zucker大鼠在两种饮食中都比不肥胖的大鼠氧化更少的脂肪，而肥胖的老鼠和不肥胖的老鼠氧化脂肪的程度相同。喂食低碳水化合物的饮食显著增加了肥胖小鼠的体重，但在肥胖大鼠和非肥胖小鼠和大鼠中没有。肥胖和低碳水化合物饮食对食物摄入、血清葡萄糖和脂质值以及二氧化碳产生的影响也有报道。
Genetically obese Zucker rats, ob/ob mice and non-obese littermates were fed low carbohydrate (2%, 48% and 50% of energy as carbohydrate, protein and fat, respectively) and control (60%, 19% and 21%, as carbohydrate, protein and fat) diets. The oxidation of the energy components of these diets was measured by adding D-[U(uniformly labeled)-14C]glucose, L-[U-14C]glutamic acid and glyceryl tri-[1-14C]oleate to test meals given intragastrically and collecting respiratory CO2 for 4 h. The animals responded to the low carbohydrate diet by oxidizing less glucose and more glutamic acid, but these amounts were proportional to dietary carbohydrate and protein composition. In contrast the animals oxidized both higher amounts and percentages of glyceryl trioleate when fed the low carbohydrate diet. Obese Zucker rats oxidized less fat than non-obese rats when fed both diets, while obese mice oxidized fat to the same extent as non-obese mice. Feeding the low carbohydrate diet significantly increased body weight in the obese mice, but not in obese rats and non-obese mice and rats. The effects of obesity and the low carbohydrate diet on food intake, serum glucose and lipid values and CO2 production are also reported.