ROLE OF DRUGS IN FRACTURES OF THE FEMORAL-NECK
ROLE OF DRUGS IN FRACTURES OF THE FEMORAL-NECK
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DOI：
10.1136/bmj.292.6524.861
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发表时间：
1986-03-29
影响因子：
105.7
通讯作者：
LOGAN, RFA
中科院分区：
文献类型：
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作者：
RASHIQ, S;LOGAN, RFA
为了调查药物在老年人股骨颈骨折发病率上升中的作用，进行了一项病例对照研究，询问处方药物的使用情况。从全科医疗记录中获取了 102 名股骨颈骨折患者的用药史，并将其与来自相同医疗机构的 204 名年龄和性别相匹配的对照患者的用药史进行了比较。骨折时，41 名骨折患者和 126 名对照患者至少服用一种处方（服用药物的患者股骨颈骨折的相对风险 = 0.42，p = 0.0006）。对于除抗生素之外的所有类型的处方药，服用药物的患者股骨颈骨折的风险低于未服用药物的患者，并且在骨折前一年的所有时间都是如此。与 37 名对照患者相比，6 名骨折患者正在接受噻嗪类利尿剂治疗（相对风险 0.28，p = 0.004）。这些结果表明，与普遍看法相反，镇静或损害姿势控制的药物并不是股骨颈骨折的重要因素。结果与噻嗪类药物引起的低钙尿症可防止骨折的假设一致，但保护程度并不明显高于其他药物的保护程度。
To investigate the role of drugs in the rising incidence of fractures of the femoral neck in the elderly a case-control study inquiring about the use of prescribed drugs was carried out. The drug histories of 102 patients with femoral neck fractures were obtained from general practice records and compared with those of 204 controls matched for age and sex from the same practices. At the time of fracture 41 patients with fractures and 126 controls were receiving at least one prescription (relative risk of fracture of the femoral neck in patients taking drugs = 0.42, p = 0.0006). For all types of prescribed drugs except antibiotics the risk of fracture of the femoral neck was less in patients taking drugs than in those not doing so, and this was true at all times in the year before fracture. Six patients with fractures were receiving thiazide diuretics compared with 37 controls (relative risk 0.28, p = 0.004). These results indicate that, contrary to popular belief, drugs that sedate or that impair postural control are not important factors in fractures of the femoral neck. The results are consistent with the hypothesis that the hypocalciuria induced by thiazides protects against fracture, but the degree of protection is not significantly greater than that associated with other drugs.