Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle.
Localization of paxillin, a focal adhesion protein, to smooth muscle dense plaques, and the myotendinous and neuromuscular junctions of skeletal muscle.
复制标题
桩蛋白（一种粘着斑蛋白）定位于平滑肌致密斑块以及骨骼肌的肌腱和神经肌肉接头。
DOI：
10.1016/0014-4827(91)90090-h
复制
发表时间：
1991
影响因子：
3.7
通讯作者：
Burridge,K
中科院分区：
文献类型：
--
作者：
Turner,CE;Kramarcy,N;Sealock,R;Burridge,K
在这份报告中，我们已经证明，桩蛋白，细胞骨架蛋白，这是目前在局灶性粘连，localizesin在vivoto地区的细胞-细胞外基质相互作用，这被认为是类似于局灶性粘连。具体地说，它是丰富的鸡砂囊平滑肌组织的致密斑块和在非洲爪蟾蝌蚪尾部骨骼肌形成myotendinous连接。此外，桩蛋白被确定在大鼠膈肌神经肌肉接头。因此，桩蛋白的分布与其他粘着斑蛋白（例如talin和黏着斑蛋白）在这些结构中的分布相当。
In this report we have demonstrated that paxillin, a cytoskeletal protein which is present in focal adhesions, localizesin vivoto regions of cell-extracellular matrix interaction which are believed to be analogous to focal adhesions. Specifically, it is enriched in the dense plaques of chicken gizzard smooth muscle tissue and in the myotendinous junctions formed inXenopus laevistadpole tail skeletal muscle. In addition, paxillin was identified at the rat diaphragm neuromuscular junction. The distribution of paxillin is thus comparable to that of other focal adhesion proteins, for example, talin and vinculin, in these structures.