Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study.
Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study.
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人类出血性中风后大脑中炎症标记的动态变化：一项验尸研究。
DOI：
10.1016/j.brainres.2010.04.033
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发表时间：
2010-06-25
期刊：
影响因子：
2.9
通讯作者：
Wang, Jian
中科院分区：
文献类型：
--
作者：
Wu, He;Zhang, Zhiyi;Hu, Xiaoli;Zhao, Ruibo;Song, Yuejia;Ban, Xiang;Qi, Jiping;Wang, Jian
本研究采用组织病理学病例对照研究方法，观察脑出血患者和非脑出血患者死后脑组织中核因子-κ B（NF-κB）/p65亚单位、巨噬细胞炎性蛋白-2（MIP-2）和基质金属蛋白酶-9（MMP-9）蛋白表达的动态变化。本研究包括36例ICH患者的人脑和6例对照脑。我们发现，在脑出血后2小时至5天的时间范围内，海马损伤侧的NF-κB/p65、MIP-2和MMP-9的表达水平均上调。有趣的是，所有三种标记物的表达也在海马体和小脑的未受伤侧上调，尽管程度较低。这些数据表明，炎症在人类ICH后早期发生并持续数天，可能参与ICH诱导的继发性脑损伤的进展。
This histopathologic case-control study was designed to characterize the dynamic changes in protein expression of nuclear factor-kappa B (NF-κB)/p65 subunit, macrophage inflammatory protein-2 (MIP-2), and matrix metalloproteinase-9 (MMP-9) in postmortem brains of patients with and without intracerebral hemorrhage (ICH). Thirty-six human brains from patients with ICH and six control brains were included in this study. We found that expression levels of NF-κB/p65, MIP-2, and MMP-9 were each upregulated on the injured side of the hippocampus at times ranging from 2 hr to 5 days post-ICH. Interestingly, the expression of all three markers was also upregulated on the uninjured side of the hippocampus and in the cerebellum, although to a lesser extent. These data suggest that inflammation occurs early and persists for several days after ICH in humans and could be involved in the progression of ICH-induced secondary brain damage.
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影响因子：
4.1
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