An (Aminopyrimidinato)titanium Catalyst for the Hydroamination of Alkynes and Alkenes
An (Aminopyrimidinato)titanium Catalyst for the Hydroamination of Alkynes and Alkenes
复制标题
DOI：
10.1002/ejoc.201301004
复制
发表时间：
2013-11
影响因子：
2.8
通讯作者：
C. Brahms;P. Tholen;W. Saak;S. Doye
中科院分区：
文献类型：
--
作者：
C. Brahms;P. Tholen;W. Saak;S. Doye
以2-（叔丁基氨基）嘧啶和[Ti(NMe2)4]为原料合成了一种新型的（氨基嘧啶）钛配合物，并将其用作炔烃分子间氢胺化反应和胺烯烃环化反应的催化剂。1-苯基丙炔和末端芳基炔的氢胺化反应产生了相应的具有优异收率和区域选择性的反马氏加成产物。
A new (aminopyrimidinato)titanium complex has been synthesised from inexpensive and easily accessible 2-(tert-butylamino)pyrimidine and [Ti(NMe2)4] and used as a catalyst for the intermolecular hydroamination of alkynes as well as the cyclization of aminoalkenes. The hydroamination reactions of 1-phenylpropyne and terminal arylalkynes deliver the corresponding anti-Markovnikov addition products with excellent yields and regioselectivities.