Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice.
Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice.
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DOI：
10.1038/s41598-017-06096-0
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发表时间：
2017-07-28
影响因子：
4.6
通讯作者：
Kato M
中科院分区：
文献类型：
--
作者：
Li X;Ohgami N;Omata Y;Yajima I;Iida M;Oshino R;Ohnuma S;Ahsan N;Akhand AA;Kato M
没有关于人类或小鼠口服砷（As）与听力损失之间关系的信息。在这项流行病学研究和实验研究相结合的研究中，研究了12-29岁人群和幼龄小鼠口服砷暴露与听力损失的关系。暴露组（n = 48）饮用砷污染的管井水的受试者在4 kHz [比值比（OR）= 7.60; 95%可信区间（CI）：1.56，57.88]、8 kHz（OR = 5.00; 95% CI：1.48，18.90）和12 kHz（OR = 8.72; 95% CI：2.09，47.77）。接下来，我们进行了一项实验，在该实验中，年轻的小鼠通过饮用水暴露于22.5 mg/L的As，这比人类研究中的浓度高得多。接触组表现为听力下降和内耳砷蓄积。离体暴露的Corti器官的小鼠暴露于As显着减少听觉神经元和纤维的数量。因此，我们的综合研究表明，口服暴露于As会导致年轻人和年轻小鼠的听力损失。
There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12–29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.
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影响因子：
4.6
作者：
Ohgami N;Yajima I;Iida M;Li X;Oshino R;Kumasaka MY;Kato M
通讯作者：
Kato M
影响因子：
5.3
作者：
Lang, HN;Schulte, BA;Schmiedt, RA
通讯作者：
Schmiedt, RA
DOI：
10.1073/pnas.1004520107
发表时间：
2010-07-20
影响因子：
11.1
作者：
Ohgami, Nobutaka;Ida-Eto, Michiru;Kato, Masashi
通讯作者：
Kato, Masashi
影响因子：
2.1
作者：
Ahn, Joong Ho;Joo, Hyun Seok;Chung, Jong Woo
通讯作者：
Chung, Jong Woo
影响因子：
10.4
作者：
BENCKO, V;SYMON, K
通讯作者：
SYMON, K