HEPATOCELLULAR-CARCINOMA - TREATMENT WITH INTRAARTERIAL IODIZED OIL WITH AND WITHOUT CHEMOTHERAPEUTIC-AGENTS
HEPATOCELLULAR-CARCINOMA - TREATMENT WITH INTRAARTERIAL IODIZED OIL WITH AND WITHOUT CHEMOTHERAPEUTIC-AGENTS
复制标题
DOI：
10.1148/radiology.163.2.3031724
复制
发表时间：
1987-05-01
期刊：
影响因子：
19.7
通讯作者：
HIROHASHI, S
中科院分区：
文献类型：
--
作者：
TAKAYASU, K;SHIMA, Y;HIROHASHI, S
31例肝细胞癌（HCC）患者接受动脉内注射碘化罂粟籽油（Lipiodol）（A组，n = 6）、碘化罂粟籽油和盐酸阿霉素（Adriamycin）乳剂（B组，n = 15）或相同乳剂随后明胶海绵（Gelfoam）颗粒化疗栓塞（C组，n = 10）。随后进行了肝切除术。在切除标本的切面上评估主病灶、子肿瘤、癌栓和囊内浸润病灶中肿瘤完全坏死的频率。C组治疗效果最好，主瘤完全坏死率为83%（P <0.01），子瘤完全坏死率为53%（P <0.01），癌栓完全坏死率为17%，囊内浸润灶完全坏死率为67%。这些结果上级优于以前报道的不加碘油的化疗栓塞。B组效果优于A组，但差异不显著。单独使用碘化油（A组）几乎没有治疗效果，但有助于区分小HCC和再生结节。
Thirty-one patients with hepatocellular carcinoma (HCC) were given either an intraarterial injection on iodized poppyseed oil (Lipiodol) alone (group A, n = 6), an emulsion of iodized oil and doxorubicin hydrochloride (Adriamycin) (group B, n = 15), or chemoembolization with the same emulsion followed by gelatin sponge (Gelfoam) particles (group C, n = 10). Hepatic resection was subsequently performed. The frequencies of complete necrosis of tumor in the main lesion, daughter tumors, tumor thrombus, and foci of intracapsular invasion were evaluated in the cut surface of the resected specimen. Group C demonstrated the best therapeutic effects, showing complete necrosis of the main lesion in 83% (P < .01), daughter tumors in 53% (P < .01), tumor thrombus in 17%, and foci of intracapsular invasion in 67%. Theseresults are superior to those reported previously for chemoembolization without iodized oil. Group B showed better results than group A, but the difference was not significant. Iodized oil alone (group A) had practically no therapeutic effect but was helpful in differentiating small HCC from regenerative nodules.